PLEASE NOTE: We are unable to offer transcripts for our programme interviews. Today is broadcast live and the running order is subject to change.
The Business Secretary, Lord Mandelson, has urged Labour MPs to back Gordon Brown and ignore a round-robin letter demanding his resignation. And President Obama is on his way to Egypt where he will deliver a speech designed to improve US relations with the Muslim world.
A video message from Osama Bin Laden has been released by al-Qaeda, ahead of President Obama's speech in the Middle East. David Makovsky, director of the Project on the Middle East Peace Process at the Washington Institute, discusses whether Mr Obama's speech will arouse expectations that cannot be fulfilled.
A round-robin letter demanding Gordon Brown's resignation has been seen by journalists. Business Secretary Lord Mandelson appealed to Labour MPs to back the prime minister. James Naughtie reports on the mood in Westminster after the week's events.
0717 Business news with Adam Shaw.
Cwm Taf NHS Trust in South Wales has been ordered to apologise to the family of a patient who died after a series of mistakes during his treatment for throat cancer. Myron Hall bled to death after a tube to help him breathe was incorrectly inserted by staff at the former NHS Trust in North Glamorgan. Astrid Coates, the solicitor for Myron's Hall's parents, explains the case.
Linguistic experts have used newly cleaned recordings to analyse Neil Armstrong's famous speech when he landed on the moon in 1969. Science correspondent Pallab Ghosh reports on whether he actually said: "One small step for a man" but the "a" got lost in space.
0727 Sports news with Garry Richardson.
The BBC has been attacked by the public accounts committee for not releasing how much it pays its top radio presenters. Committee chairman Edward Leigh and Jeremy Peat, of the BBC Trust, discuss whether the information should be released.
0741 Today's papers.
The world's largest and most high profile contemporary art show, the Venice Biennale, is to open to the public. Exhibitors include film-maker and Turner Prize-winning artist Steve McQueen and former member of the Velvet Underground John Cale. Arts correspondent Rebecca Jones reports from Venice where competitors are vying for the top prize - the Golden Lion.
0749 Thought for the day with Dr David Wilkinson, principal of St John's College, Durham.
It is 20 years ago since tanks crushed protests in Tiananmen Square, Beijing. Correspondent John Simpson was reporting for the BBC that day, and Andrew To was in Tiananmen just before the massacre. They discuss the events and how the anniversary is being commemorated.
"You can best serve the country by stepping down as party leader," a draft email to Gordon Brown signed by MPs, says. Political editor Nick Robinson reports on how many Labour politicians could sign it.
US President Barack Obama is preparing to give a much-anticipated speech in Cairo, on the second leg of his tour of the Middle East and Europe. Madeleine Albright, secretary of state under President Clinton, and Amr Moussa, secretary-general of the Arab League, discuss if it can provide a fresh start to an old relationship strained for many years.
Orwell's voice was 'unsuitable'
The BBC is launching an online collection of George Orwell's work to mark the 60th anniversary of the publication of his novel 1984. Jean Seaton, the BBC's official historian, talks about the collection.
0827 Sports news with Garry Richardson.
The question of whether animals should be used for tests in laboratories is to be debated at the Cheltenham Science Festival. Dr Kelly Berube, cell biologist at Cardiff University, and Dr Peter Kohl, of Oxford University, discuss the issue.
It is 30 years since Factory Records, the Manchester-based indie music label behind bands like Joy Division and the Happy Mondays, was born. Reporter Nicola Stanbridge investigates whether the label contributed significantly to the regeneration of Manchester.
Ever heard of the thriller writer Eric Ambler? Mark Mazower, professor of history at Columbia University, and Joyce Fowell, Eric Ambler's sister, discuss why he has virtually disappeared.
Expectations are high today that President Obama might change the relationship between the US and the Muslim world with his speech in Cairo. Author Reza Aslan and Abdel Bari Atwan, editor of Al Quds newspaper, discuss if one address can have such a large impact.
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