New research from the University of Manchester appears to show that Freud's claim that guilt plays a key role in depression is true.
Researchers found that the brain scans of people with the history of depression differed when asked questions associated with guilt from people who never get depressed.
Dr Roland Zahn, senior lecturer in psychology and psychiatry at Manchester University, explained that brain scans of people with a history of depression indicated that they differed in their feelings of guilt compared to those that never get depressed.
He said that researchers think that these feelings of depression are something that "we can change" in the brain.
"The feeling of guilt was specifically chosen to be investigated because it is an emotion linked to clinical depression and excessive guilt is a symptom of depression."
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