Referees and linesmen have been in the spotlight in Japan and South Korea after a number of crucial goals were disallowed.
Italy had five goals ruled out through potentially dubious offside calls, while Spain's golden-goal winner against South Korea was cancelled despite appearing legitimate on replays.
Several key bookings and sendings off have also been criticised.
It's useless just changing the referees - we have to think how we can help them
Wenger says that, rather than persecute officials, governing body Fifa should devise ways of helping them.
"Some of the decisions have been unfair, but then football is often unfair," Wenger told Arsenal's official website.
"Perhaps we should decide to use video replays for some special incidents. It's useless just changing the referees - we have to think how we can help them.
"And I have also seen some very good things at the World Cup.
"There have been cheats who have been sanctioned and shirt-pulling in the box has resulted in penalties.
"Things like that are an improvement and very good for the game."
Fifa has said it plans to experiment with a fourth official behind the goals next season in an effort to reduce mistakes.