Enjoyed a remarkable run here in 2001, his victims including Greg Rusedski and Marat Safin before he fell to Alex Corretja in the last 16.
Known as 'The Magician' he cuts a distinctive figure on court, making up for what he lacks in stature with a full range of shots.
His deft touch is coupled with a relentless playing style - despite his veteran status and a recurring shoulder injury.
Santoro collected his fourth career title earlier this year when he triumphed over Younes El Aynaoui in the final at Dubai.