Although Hampden has hosted many of Uefa's finals over 60 years of continental competition, this season's showcase final between Sevilla and Espanyol on Wednesday will be the first time the Uefa Cup has climaxed in Glasgow.
And, as up to 40,000 Spanish fans descend on Glasgow daring to dream that their side will lift the trophy, we take a look back at the previous European finals held at Scotland's national stadium.
1960 European Cup Final
The Spanish side were led superbly by the Hungarian "Galloping Major" Ferenc Puskas and Argentinean maestro Alfredo di Stefano, who scored four and three goals respectively in the final.
Rangers were Scotland's representatives in that season's competition and made it to the semi-finals, knocking out Anderlecht, Red Star Bratislava and Sparta Rotterdam in the process.
The Ibrox men were overwhelmed by Eintracht Frankfurt in the semi-final, however, being trounced 6-1 in Germany and 6-3 in Glasgow.
1962 Uefa Cup-Winners' Cup Final
Atletico did things the hard way, however, drawing 1-1 with Fiorentina at Hampden before winning the replay 2-1 in Stuttgart.
Dunfermline flew the flag for Scotland in that season's competition and the Fife club, under the management of Jock Stein, made it to the quarter-finals before losing out to crack Hungarian outfit Ujpest Dosza by an aggregate score of 5-3.
1966 Uefa Cup-Winners' Cup Final
It was heartbreak for Scots Bill Shankly, Ian St John and Ron Yeats at Hampden in 1966 as their Liverpool side went down to a 2-1 defeat at the hands of Borussia Dortmund after extra-time.
A crowd of 41,000 saw the Germans take the lead in the 62nd minute through Held before Roger Hunt equalised. Reinhard Libuda grabbed the winner with only 10 minutes of extra-time remaining to give the Rhinelanders their first European triumph.
Jock Stein, now managing Celtic, led the Scottish challenge again and the Glasgow club performed well, reaching the semi-finals.
Despite winning the first leg of the tie 1-0, Stein's side went down 2-0 at Anfield - it would take another year before Celtic were to taste European glory.
1976 European Cup Final
St Etienne stood in their way and came close to causing an upset in a game of few chances. Jacques Santini hit the woodwork, but the shot rebounded wide, leaving Frenchmen rueing Hampden's square goalposts. Franz Roth's solitary goal was enough for Bayern to win 1-0.
Just like in 1960, Rangers were the Scottish representatives in Uefa's premier competition and were again beaten by the losing finalists.
This time, however, Rangers could not progress as far in the competition, losing 4-1 to St Etienne on aggregate in the second round.
2002 Champions League Final
Real Madrid returned to Hampden Park for the final of the 2001-02 Champions League, where they faced surprise German package Bayer Leverkusen.
Leverkusen, never the most popular club in their homeland, lived up to the mocking epithet "Neverkusen" given them by rival fans as they fell 2-1 to the Spanish giants.
Zinedine Zidane gave a masterclass in midfield for Madrid, scoring the decisive goal with a sublime volley from the edge of the area.
Both sides of the Old Firm were involved in the Champions League, but while Celtic managed to qualify for the group stages courtesy of a 3-2 victory over Ajax, Rangers fell at the third qualifying stage, losing narrowly to Turkish outfit Fenerbahce.
Celtic failed to qualify for the latter stages of the competition, failing to qualify for the second group stage by a single point, despite a 4-3 home win over Juventus.
Hampden now looks forward to hosting its sixth European final. Will the seventh see a Scottish side contest it?