South Africa have made a late change to the side to face Scotland, with Ricky Januarie replacing scrum-half Fourie du Preez, who was injured in training.
It is the only alteration to the team that won 20-15 in Wales last weekend.
The Scots also make one change after the heavy defeat to New Zealand, with fit-again Rory Lamont replacing his brother Sean on the left wing.
The match against the Springboks will be the Sale player's first cap since March's Calcutta Cup victory.
Rory comes in after Sean was ruled out of Scotland's remaining autumn Tests with a hamstring injury sustained in the 32-6 loss to the All Blacks.
Captain John Smit, who will win his 80th cap on Saturday to equal Os Du Randt's Springboks record for a forward, will remain in his new role at tight-head prop, having switched from hooker.
"We were a bit lacklustre against Wales but you shouldn't under-estimate the advantage of playing at home," Smit said.
"We were pleased that Wales were unable to score any tries against us. We've put a lot of work into defence."
Januarie's spot on the world champions' bench has been handed to utility forward Danie Rossouw.
Scotland retained Simon Webster in their squad as cover after winger Thom Evans missed training on Monday with a stiff neck.
"Alasdair Strokosch can consider himself very unlucky"
However, there have been no further call-offs for what Hadden expects to be a robust battle of the packs.
"If you don't front up physically against South Africa, you don't get into the game," said Hadden.
"We're expecting a big confrontation and that is reflected in the pack we've gone for.
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"We created a lot of opportunities against New Zealand. We're determined to turn them into points this weekend."
Hadden said Strokosch was not too far away from a place in the starting line-up.
"Strokosch can consider himself very unlucky," added the coach.
"But Jason is way ahead of Al in terms of his understanding of the line-out."
There was no place in the pool for Simon Taylor, who was forced to withdraw from the starting line-up on Saturday with a calf strain.
Scotland: Chris Paterson, Thom Evans, Ben Cairns, Nick De Luca, Rory Lamont, Phil Godman, Mike Blair (capt), Allan Jacobsen, Ross Ford, Euan Murray, Nathan Hines, Jim Hamilton, Jason White, John Barclay, Allister Hogg.
Replacements: Dougie Hall, Alasdair Dickinson, Matt Mustchin, Scott Gray, Rory Lawson, Dan Parks, Hugo Southwell.
South Africa: Conrad Jantjes, J P Pietersen, Adi Jacobs, Jean de Villiers, Bryan Habana, Ruan Pienaar, Ricky Januarie; Tendai Mtawarira, Bismarck de Plessis, John Smit (capt), Bakkies Botha, Victor Matfield, Schalk Burger, Juan Smith, Pierre Spies.
Replacements: Brian Mujati, Gurthro Steenkamp, Andries Bekker, Ryan Kankowski, Danie Rossouw, Francois Steyn, Jaque Fourie.
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