The Ospreys moved closer to Heineken Cup qualification by hitting Connacht with seven tries in Galway.
Winger Jonny Vaughton got three tries with fly-half Shaun Connor, hooker Huw Bennett, replacement flanker Lee Beech and centre Sonny Parker also crossing.
Wales Under-21 fly-half James Hook, who will travel to Argentina with the senior squad in June, came on for his first appearance since September 2004.
Connacht only trailed 17-16 at the interval by were overwhelmed late on.
The Ospreys set the ball rolling in the fourth minute. Parker bulldozed up the Connacht line before flicking a pass for Connor to scoot in at the corner.
The classy Connor then sliced through the Connacht defence to set up Bennett's score on 23 minutes.
"Getting people back onto the field after injury and suspension has been the key"
Gavin Henson converted and four minutes later, slick hands from Jonathan Thomas, Connor and Henson sent Vaughton scurrying down the touchline for an excellent score and a 17-6 lead.
A breakaway try from centre John Hearty in first-half injury time kept the province keep in touch at the interval.
Despite having back row Richie Pugh binned for a ruck offence, the Ospreys easily controlled the second half.
Henson landed a penalty to push himself through the 600-point mark in the league.
Beech (62), Vaughton (69, 72) and Parker (80) shared out the tries with Vaughton's hat-trick score seeing him outpace Conor McPhillips down the left wing.
Neath starlet Hook, making only his second appearance in an Ospreys shirt, converted his side's final two tries.
"Things have changed since our loss to the Blues in March and we're carrying a lot of momentum into the end of the season.
"Getting people back onto the field after injury and suspension has been the key.
"Shane Williams, Gavin Henson and Andy Lloyd have been important, Ian Evans and Alun Wyn Jones have stood up and given us an extra dimension, and the front row have been immense all year."
Connacht: Slemen, Mostyn, Hearty, Williams, Yapp, McHugh, Keane, Hogan, Fogarty, Knoop, McGowan, Farley, Muldoon, Lacey, Rigney.
Replacements: McPhillips for Slemen (59), Warwick for McHugh (63), Merrigan for Fogarty (65), Gannon for Farley (15). Not Used: Clarke, Swift, Tierney.
Ospreys: Henson, Vaughton, S. Parker, A. Bishop, S. Williams, Connor, Spice, D. Jones, Bennett, A. Jones, A. Jones, Evans, Thomas, Pugh, Lloyd.
Replacements: Hook for Connor (64), S. Terblanche for Spice (76), James for D. Jones (76), B. Williams for Bennett (34), Griffiths for A. Jones (69), Bateman for Wyn Jones (78), Beech for Lloyd (58).
Referee: Peter Allan (Scotland).