England's pack produced a powerful display as they began their Six Nations campaign with victory against reigning Grand Slam champions Wales.
Tries from Mark Cueto and Lewis Moody gave England a 15-10 lead, with Martyn Williams replying for Wales.
Mike Tindall scored England's third try after the break before three late scores saw the home side pull away.
Lawrence Dallaglio and Matt Dawson both went over from late scrums before Tom Voyce rounded things off.
Wales had not won at Twickenham since 1988 and, although England's backs continued to look some way short of the highest level at times, the world champions' overall power was enough to subdue the visitors.
Match statistics
Wales were missing half-a-dozen players through injury or suspension and in the end their lack of strength in depth was brutally exposed.
"The autumn set a benchmark for our performances and that was a level up"
England opened the scoring when Jamie Noon burst through the Welsh midfield after 14 minutes, and Cueto was on his shoulder to cut through the remaining defence and score an excellent try.
Charlie Hodgson converted but Harry Ellis almost immediately conceded a penalty at a scrum, allowing Stephen Jones to get Wales on the board.
More England reaction
Wales winger Mark Jones then gave England two penalties in quick succession, and they cost the visitors eight points.
First, Hodgson slotted a long-range penalty before Moody scored from a driving maul which rumbled through the Wales defence.
Wales hit back after 34 minutes when livewire scrum-half Dwayne Peel cut through from a line-out and Martyn Williams was in support to claim the try, with Stephen Jones converting.
Two Hodgson penalties, to one from Stephen Jones, made it 21-13 after 55 minutes, with Wales a man down after Martyn Williams was sin-binned.
"The sin-binning of Martyn Williams was a crucial moment"
Thanks to their forwards, England were winning plenty of ball, and, although the backs were not always clicking, the hosts extended their lead when Tindall finished off a move which went three-quarters the length of the field.
Hodgson missed the conversion but was on target when Dallaglio marked his recall to England colours by powering through Stephen Jones from the base of a five-metre scrum.
More Wales reaction
Andy Goode, on for Hodgson, converted and then added the extras when Voyce finished off a fine move to claim England's sixth and final try.
England: Lewsey; Cueto, Noon, Tindall, Cohen; Hodgson, Ellis; Sheridan, Thompson, Stevens, Borthwick, Grewcock; Worsley, Moody, Corry (capt).
Replacements: Mears, White, Shaw, Dallaglio, Dawson, Goode, Voyce.
Wales: G Thomas (capt); M Jones, Luscombe, Watkins, S Williams; S Jones, Peel; D Jones, R Thomas, AR Jones, Gough, Sidoli, Charvis, M Williams, Owen.
Replacements: M Davies, G Jenkins, AM Jones, Popham, Cooper, N Robinson, Byrne.
Referee: Paul Honiss (New Zealand)