British swimmer Dave Roberts broke the world record in his 400m freestyle final to win his third gold of the Games and 10th Paralympic title.
The 28-year-old Welshman's time of four minutes, 52.35 seconds, beat America's Lantz Lamback by four seconds.
He told BBC Sport: "It wasn't a great swim, I wanted to go seven seconds quicker, but it's a gold medal."
South Africa's Natalie du Toit won her 200m individual medley event by 10 seconds for a third gold at the Games.
Du Toit lowered her own world record to 2:27.83 to underline her supremacy as Canada's Stephanie Dixon picked up silver.
606: DEBATEBritain's Louise Watkin was third in 2:40.31 to add a bronze medal to the silver and bronze she won earlier in the week.
But Claire Cashmore missed out on a medal, finishing two seconds further back in fourth.
Fellow Brit Heather Frederiksen produced a stunning last 50m to touch out Russia's Olesya Vladykina and take bronze in the in 200m individual medley (SM8).
The 22-year-old, who won 100m backstroke gold on Wednesday, said: "I knew I was going into the final fourth fastest and I would have to fight for a medal and I found something deep inside to win that medal.
"I've now got a collection of gold, silver and bronze from three races, so I am happy."
Australia's Peter Leek won the corresponding men's race, breaking his own world record by five seconds.
And Sam Hynd, who reached the final as the second fastest qualifier, won a third British bronze after being edged out of the silver medal position by 0.20 seconds by China's Jiachao Wang.
The 17-year-old said: "It was a good swim from Wang and I thought I would pip him at the line.
"It is my first medal and I get to go on the podium before my main event on Friday."
Robert Welbourn finished seventh in the final of the men's 200m individual medley (SM10).
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