Eli Manning threw two touchdown passes as the New York Giants crushed Seattle 44-6 to improve to 4-0 for the season.
The Super Bowl champions are the only unbeaten team in the National Football Conference, while Seattle slip to 1-3.
Brandon Jacobs rushed for two more scores and the Giants defence held the Seahawks without a touchdown.
The home team laid down a marker on their first series, with Manning throwing a 32-yard TD pass to Domenik Hixon, and they never eased up.
Manning connected with Sinorice Moss for a second touchdown in the third quarter.
Moss had another TD pass, this time from Manning's replacement David Carr, to wrap up the scoring in the fourth quarter.
First-half runs of three and one yards gave Jacobs his touchdowns. He also had 136 yards rushing.
Tennessee also remained unbeaten (5-0) thanks to a Alge Crumpler touchdown off a Kerry Collins pass with less than two minutes left in the game.
The Titans were trailing 10-6 before Collins directed the 11-play, 80-yard scoring drive that secured a 13-10 win over the Baltimore Ravens (2-2).
The Indianapolis Colts (2-2) scored 21 points in the closing minutes to record a stunning 31-27 victory over Houston (0-4).
They secured two touchdowns thanks to fumbles by Texans quarterback Sage Rosenfels and then intercepted Rosenfels' last-ditch comeback attempt.
Clinton Portis ran for 145 yards and had one touchdown and wide receiver Antwaan Randle El threw a touchdown pass as the Washington Redskins beat the Philadelphia Eagles to move to 4-1 under new coach Jim Zorn.
Ryan Longwell kicked a 30-yard field goal with 13 seconds remaining to secure a 30-27 victory for the visiting Minnesota Vikings over the New Orleans Saints on Monday.
The Vikings rallied from seven points down in the final quarter to claim victory.
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