Green Bay quarterback Brett Favre threw his 421st career touchdown pass against the Minnesota Vikings on Sunday to move clear of Dan Marino's all-time record.
Favre, in his 17th NFL season and turning 38 next month, tied the mark against San Diego a week ago.
Greg Jennings, who caught Favre's 420th pass, was also on the end of the 421st, a 16 yarder in Minneapolis.
James Jones caught number 422 in the fourth quarter as the Packers stayed unbeaten this year with a 23-16 win.
After Jennings completed the first-quarter catch-and-run, Favre sprinted to hoist the receiver on his left shoulder as thousands of travelling Packers fans cheered.
Even home fans stood and applauded when the announcement was made, and a taped message from Marino played on the big screen.
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"I loved holding the touchdown record for the past 13 years," Marino said.
"But if someone was going to break it, I'm glad it was someone like you, who has always competed at the highest level and always played to win."
Marino, who starred for the Miami Dolphins between 1983 to '99, played most of his career before rule changes which made it easier for teams to pass the ball regularly.
Favre already holds the marks for career pass completions and consecutive starts by a quarterback, which hit 241 on Sunday.
Two weeks ago, Favre led the Packers past the Giants for his 149th win as a starter, passing John Elway's record.
Favre's 45 pass attempts in the game moved him 34 clear of Marino's record in that category too, taking his total to 8,349.
He went without an interception against the Vikings and remains three short of former Oakland Raider George Blanda's all-time mark in the most ignominious statistical mark for quarterbacks.
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