Tyrone boss Mickey Harte has revealed attackers Stephen O'Neill and Martin Renrose will definitely miss the 20 May Championship clash with Fermanagh.
O'Neill is struggling with a hamstring injury, while Penrose was carried off during a club game with knee damage.
Harte admitted he was worried about the blow to Aghyaran club man Penrose.
"I think it is a lateral ligament in his knee. It could be as long as 10 weeks. Hopefully it will not be as long as that," said the Red Hands supremo.
"It certainly will be a minimum of six weeks so it puts him out of the Fermanagh game, and probably whatever game we play after that."
A number of other Tyrone men are rated as doubtful for the Clones clash.
"Owen Mulligan has a hamstring injury and Raymond Mulgrew has a knee problem and both are serious doubts," added Harte.
"Joe McMahon has a shoulder injury, which I do not think is as serious as the other ones, but it is going to curtail him.
"Kelvin Hughes has injured his ankle, Mickey McGee has a sore shoulder. It sounds like a litany of stuff, but it is a fact.
"There are about eight players at the moment who, if the game was tomorrow, would not be able to play."
Harte did not rule out a place on the bench for Brian McGuigan, who last played for Tyrone in the 2005 All-Ireland final, and has been out action for more than a year after breaking a leg.