Formula One supremo Bernie Ecclestone said the race could be dropped from the World Championship calendar in 2003 if no concession is made.
The news comes just days after questions were raised over next year's British Grand Prix.
The sport's governing body, the FIA, will meet in Monte Carlo on Friday to discuss the Silverstone event after problems with traffic and access in the last two years.
Now the Belgian Grand Prix could also be on the agenda.
"We will not necessarily hold a Belgian GP in 2003," Ecclestone told Autosport magazine.
"It is not out of the question, despite the track usually being included on the calendar."
"Belgium must adopt the same stance as the rest of Europe, where tobacco advertisement is permitted until 2006.
"We cannot make exceptions for certain organisers."
Legal action
The FIA has said it wants to ban all tobacco sponsorship by the end of the 2006 season.
It is not the first time the future of the Spa Francorchamps circuit has been called into question.
Two years ago the Belgian government threatened legal action against any teams running with tobacco advertising.
And in 1997, Ecclestone also threatened to axe the race when Belgium's parliament first approved a law, tougher than European Union legislation, against tobacco advertising.
Russia is expected to seek a place on the 2003 race calendar meaning another European grand prix could be dropped to make way.