Carlisle staged a stirring second-half revival to put an end to Leeds's 13-game unbeaten league run.
Leeds dominated before the break and took the lead when Jermaine Beckford coolly slotted in from 10 yards.
But Carlisle got their act together in the second-half and Simon Hackney's superb 25-yard strike drew them level.
Joe Garner's close-range header from a well-worked corner made it 2-1 and Mark Bridge-Wilkinson secured a third win on the trot with a precise late finish.
Carlisle: Westwood, Raven, Livesey, Murphy, Aranalde, Anyinsah (Gall 72), Bridge-Wilkinson, Lumsdon, Hackney, Graham, Garner (Carlton 90).
Subs Not Used: Howarth, Arnison, Smith.
Booked: Bridge-Wilkinson.
Goals: Hackney 61, Garner 70, Bridge-Wilkinson 90.
Leeds: Ankergren, Richardson, Marques, Heath, Clapham (Huntington 90), Prutton (Constantine 76), Douglas, Hughes, Carole (Da Costa 76), Beckford, Kandol.
Subs Not Used: Lucas, Weston.
Booked: Clapham, Prutton, Heath, Hughes, Kandol.
Goals: Beckford 28.
Att: 16,668.
Ref: Phil Dowd (Staffordshire).
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