Carlos Moya arrives at Flushing Meadows suffering a crisis of confidence after three straight first-round defeats.
World ranking: 7
US Open best:
2002: 2nd round
2001: 3rd round
2000: 4th round
It is five years since Moya lost in the US Open semi-finals to Mark Philippoussis, and since then he has fought back from a career-threatening injury.
The 27-year-old Spaniard also won the French Open in 1998 and briefly reached the top of the world rankings the following year.
Two years of back problems followed, but Moya re-established himself as a major force in the game last year, winning four ATP titles and returning to the world's top 10.
Moya has continued his resurgence this year, winning in Buenos Aires, Barcelona and Umag, and losing out to Andre Agassi in the final of the Nasdaq in Miami.
But there have been some surprising defeats recently to the likes of Tomas Behrend, Albert Portas and Fabrice Santoro.
A quarter-final defeat on his favoured clay at the French Open was also disappointing and Moya may find it tough to live up to his seeding in New York.