Venue: Queen's Club Date: 7-13 June
Coverage: Live video on BBC Two, Red Button and BBC Sport website (UK only); also live on Eurosport. Updates on Radio 5 live and live commentary from quarter-finals onwards; live text commentary online for all Andy Murray matches
Details of BBC coverage
Roddick fails in his bid to win a fifth title at Queen's Club
Three of the top five seeds tumbled out at Queen's on Thursday with second-ranked Novak Djokovic, Andy Roddick and Marin Cilic all third-round casualties.
World number three Djokovic lost 6-3 4-6 6-2 to Xavier Malisse, while Roddick, the four-time champion, fell to Israel's Dudi Sela in straight sets.
Marin Cilic, Croatia's fifth seed, was defeated by France's Michael Llodra.
French Open champion Rafael Nadal overcame a minor hamstring injury in his three-set win over Denis Istomin.
The Spaniard, world number one and 2008 Queen's champion, was given an almighty scare by Istomin with Uzbekistan's rising star taking the second set and pushing him close in the decider.
Nadal survives Queen's scare
After needing a medical time-out to have a massage on his right leg, Nadal had to save two break points in the seventh game before needing three match points to finally come through 7-6 (7-4) 4-6 6-4 against an opponent ranked 72nd in the world.
Nadal, who faces Feliciano Lopez in the quarter-finals at the Aegon Championships, said: "I'm going to have the leg tested. The pain started slowly and then I felt it more.
"I'm not thinking about pulling out of the tournament. I'm sure I'll play Friday. I'll be very careful but should be OK."
On a day of big shocks, Djokovic fought his way back to one-set all before crashing out to Belgium's Malisse, who next plays Sam Querrey of the United States, a 6-4 7-6 (7-5) winner over Marcel Granollers.
Serbia's Djokovic, who had his match shifted from Centre Court at the end of another rain-affected day in London, was unhappy at being forced to play on a damp court.
"The conditions were impossible," the 23-year-old said. "Under these conditions, to be able to play a professional tennis match, this is ridiculous.
"A couple of times I could have injured myself, to stretch the muscle or something like that."
Israeli Sela caused the first upset of the day with a 6-4 7-6 (10-8) win over fourth seed Roddick.
Roddick pulls off odd drop-shot
Sela broke the famous American serve once to take the first set and then saved two set points in a gripping second-set tie-break before securing victory with a spectacular diving volley.
Roddick's defeat marks the first time he has failed to reach at least the semi-finals at Queen's Club since his first appearance in 2001.
"He outplayed me", Roddick admitted. "He played a pretty perfect match."
Since 2001, he has won the title four times and lost in the semi-finals three times.
It was a disappointing way to begin his preparations for Wimbledon, where he lost in the final for the third time last year.
But the 27-year-old insisted: "I'm not super concerned about the way I'm hitting the ball, I'm not stressing out about any one part of my game too much."
Cilic suffered a shock 7-6 (7-2) 6-2 defeat to Llodra of France, who will play the winner of Andy Murray and Mardy Fish for a semi-final spot.
Sela's next opponent, German Rainer Schuettler, was handed a walkover into the last eight when 11th seed Richard Gasquet pulled out with a back injury.