Djokovic on his way to defeat at the tournament in Miami
Novak Djokovic suffered a shock defeat in the second round of the Sony Ericsson Open in Miami on Friday, losing to Belgian Olivier Rochus.
The world number two, who won the tournament three years ago, was beaten 6-2 6-7 (7-9) 6-4 in an error-strewn performance.
He double-faulted 10 times and made 62 unforced errors, before leaving the court to jeers from some of the crowd.
Rafael Nadal and Andy Roddick both made solid progress on a rain-affected day.
Fourth seed Nadal saw off big-serving American Taylor Dent 6-3 6-3 in only 70 minutes, and said: "It was a good start for me.
"Playing against Dent is always a difficult match because you don't have rhythm."
He was motivated to win against somebody who's better ranked, top player. He didn't have anything to lose
Sixth seed Roddick defeated Igor Andreev 6-4 6-4, while French eighth seed Jo-Wilfried Tsonga beat Guillermo Garcia-Lopez 6-4 6-3.
Ivan Ljubicic, the surprise winner in Indian Wells last week, was forced to retire with a back injury when leading Benjamin Becker 6-4 1-0.
Wildcard David Nalbandian battled to a 6-3 4-6 6-4 win over 30th seed Viktor Troicki as the Argentine makes his back after injury.
The major talking point of the day was the exit of Djokovic, who lost his cool and slammed his racquet into the court at one point as he went down in just under three hours.
Their match had been delayed for two-and-a-half hours because of a rainstorm and was interrupted for almost an hour after the ninth game when more bad weather hit the venue.
"He was motivated to win against somebody who's better ranked, top player," said the Serb. "He didn't have anything to lose.
"He picks up the ball very early and he runs all over the court. He was playing really well today, so I want to congratulate him. Definitely he deserves it."
"I never expected to win," said Rochus, ranked 59th in the world. "Novak, he has won a Masters Series five times; he won a Grand Slam, many things I have never did in my life. He is number two, so I think he has more experience than me."