Bartoli has struggled with injuries this season
Marion Bartoli's bid to repeat last year's unlikely run to women's singles final at Wimbledon was ended in the third round by Bethanie Mattek.
The French 11th seed, hit by injuries and poor form since losing to Venus Williams last July, was beaten 6-4 6-1.
At one stage during the first set, when she was 5-4 down, Bartoli called for a trainer to treat a stiff shoulder.
Mattek, 23, ranked 69th in the world, has never previously gone beyond the second round of any Grand Slam event.
She now faces fellow American and two-time Wimbledon winner Serena Williams who saw off 2006 winner Amelie Mauresmo 7-6 (7-5) 6-1.
Svetlana Kuznetsova reached the fourth round with a 6-2 6-4 win over Barbora Zahlavova Strycova, who was angered by the slippery conditions on a day which saw the first rain delay of the Championships.
The fiery Czech was warned for an audible obscenity in the first set after losing her temper and shouted: "Oh, my God, this is unbelievable."
Kuznetsova, the highest-ranked Russian after Maria Sharapova's shock exit, was inconsistent but too good for Strycova.
After a rain delay, she dropped her serve twice in a messy second set before securing the win on her 23rd birthday.
She told reporters she was heading into central London for a Japanese meal with friends but would not be going wild.
"Hopefully we can have a good time but I cannot have a big celebration, otherwise it's not Wimbledon for me anymore," she said.
Czech 18th seed Nicole Vaidisova eased into the last 16 with a 6-2 6-4 win over Casey Dellacqua.
Vaidisova beat another Aussie, Sam Stosur, in the previous round
A quarter-finalist last year, she easily took the first set in 23 minutes and kept up the pressure in the second set to break for a 3-2 lead.
A rain delay at 4-3 gave Dellacqua a chance to regroup but when play resumed Vaidisova held serve to seal victory.
Twice a Grand Slam semi-finalist, Vaidisova is now working with David Felgate, the former coach of Britain's Tim Henman, after a poor run of results earlier this year.
"I made some changes in my team, a new coach, but the changes needed some time. It doesn't come overnight, so I'm definitely happy it's paying off and I'm showing some progress," she said.
"David is a very positive guy, very patient. It's just exciting to do things a little differently. It's a good challenge for both of us."
Vaidisova now plays Anna Chakvetadze for a place in the quarter-finals after the Russian eighth seed beat compatriot Evgeniya Rodina 6-4 6-3.
Agnes Szavay set up a last-16 meeting with Jie Zheng, the surprise conqueror of top seed Ana Ivanovic, after beating Anabel Medina Garrigues of Spain 7-6 (7-5) 2-6 6-2.