Murray now faces Malisse on Thursday and added: "I practised with him a lot at Nick Bollettieri's and he is a very talented player. He is not playing as well as he did when he reached the semi-finals here but he plays very well on grass."
Santoro enjoyed the experience of his Centre Court debut despite the defeat.
"It was as good as I was thinking it would be," he said.
"The most special thing was the walk from the locker room to Centre Court. At that point you are conscious of what had happened here and who walked in this corridor in the last century.
"We played quite a good match even if it was straight sets. I played better than in the last few days when practising. I think I had chances in the second set but I didn't take them but when you are two sets down it is more and more difficult."
This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.