Murray dominated Simon with some solid clay-court tennis
Andy Murray set up a third-round encounter with Rafael Nadal at the Hamburg Masters as he breezed past Gilles Simon of France 6-3 6-3.
Murray lost his only previous meeting with Simon last year, but the Scot set the tone for a comprehensive win by breaking serve in the very first game.
World number one Roger Federer strolled past Finn Jarkko Nieminen 6-1 6-3 and third seed Novak Djokovic also won.
Spaniard Nadal beat Italy's Potito Starace 6-4 7-6 (8-6).
"I didn't have much time to practice, because of a blister on my foot, so I am reasonably happy to get through," said Nadal.
"I have had two tough games against Andy already this year and I expect the same."
Murray said he would be very much the underdog against Nadal.
"I'm not expected to win the match at all," said Murray, who turns 21 on Thursday.
"But if I can perform as I did today I think I can give him a good game. It was a very good win.
"Simon has beaten a lot of top guys on clay and is a very tough clay-court player. I was happy to finish it off so professionally."
Murray will need to up his game against the player acknowledged as the world's best on clay, but there were some promising signs in his emphatic defeat of Simon.
A fantastic lob in the opening game sealed his opening-game break, and he went on to hold serve comfortably and then break again as he established a 4-1 lead.
Simon stopped the rot by taking his first break point to reduce his arrears, but Murray had already done the crucial damage and went on to seal the set 6-3 with another break.
The Scot then won his third game in a row to get off the mark in the second set before Simon levelled.
Simon showed superb form in flashes, but unforced errors let Murray keep his nose in front.
Murray benefitted from a series of Simon errors to break and take a 5-3 lead and he went on to recover from 40-0 down in the final game to seal the victory.
Djokovic downed Juan Ignacio Chela of Argentina 6-3 6-1, seventh seed James Blake lost 6-4 3-6 3-6 to Serbia's Janko Tipsarevic and 13th-seed Tommy Robredo crashed out to Croatia's Ivo Karlovic after losing 3-6 6-2 7-6 (7/3).
Frenchman Jo-Wilfried Tsonga, the 14th seed, went down in straight sets 6-2 7-5 to Sweden's Robin Soderling but former world number one Marat Safin continued his comeback with a straight-sets win over ninth-seed Tomas Berdych in the second round.