Tsonga (left) and Nadal share a 1-1 head-to-head record
Rafael Nadal has a chance to avenge his Australian Open semi-final upset by Jo-Wilfried Tsonga in the fourth round of the Pacific Life Open.
Nadal, who is defending champion in Indian Wells, saw off up-and-coming American wildcard Donald Young 6-1 6-3.
Tsonga, now the world number 17, beat fellow Frenchman Paul-Henri Mathieu 7-6 (7-5) 6-4 to set up the Nadal tie.
Female top seed Ana Ivanovic also advanced to the fourth round with ease, dispatching Tathiana Garbin 6-3 6-0.
Nadal took advantage of Young's early nerves to romp away with the first set, although the 18-year-old provided stiffer resistance in the second.
But the American was unable to capitalise on his one break point at 3-5 down and Nadal served out for the match.
"All matches are important for me but especially here where I am defending my title because last year I played my best tournament here," he said.
"It's going to be important for me to serve well against Tsonga. He's strong in his serve.
"From the baseline I must try to play a little bit more aggressively than in Australia."
Australian Open champion Novak Djokovic moved into the fourth round with a 6-3 6-2 win over Germany's Philipp Kohlschreiber.
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Feature: Behind the scenes at Indian Wells
"I think I have gained something in my game," revealed the 20-year-old after winning in just over an hour.
"I have figured out with experience how I should play in the first couple of rounds."
French eighth seed Richard Gasquet blasted past Juan Ignacio Chela 6-2 6-1 to set up a meeting with ninth seed, American James Blake, who beat Carlos Moya 6-3 6-4.
The upset of the day went to unseeded world number 52 Hyung-Taik Lee, who edged past Spanish fifth seed David Ferrer 7-6 (7-5) 6-7 (5-7) 7-6 (7-3).
There was no problem for women's top seed Ivanovic as she saw off Garbin to set up a fourth-round match with Italian 13th seed Francesca Schiavone, who beat compatriot Flavia Pennetta 6-3 6-4.
"That's very positive," commented Ivanovic. "I finished the match strongly and did some things I was practising and working on, so I'm happy about that."
Jelena Jankovic saw off Japanese veteran Ai Sugiyama 6-1 6-1, despite having her serve interrupted by swirling winds throughout the match.
"I really tried to do my job out there, I didn't want to let her get into the match," said Jankovic.
Jankovic coped with swirling breezes in California to advance
"Especially with the wind you cannot lose your concentration because as soon as you do that you start making a lot of errors and then you lose your rhythm.
"I was tossing it and I had a different toss every time."
American Lindsay Davenport battled through an error-strewn match to eventually notch up a 6-4 5-7 6-2 win over Taiwan's Chan Yung-Jan.
"It was tough," added Davenport, who won the Indian Wells crown in 1997 and 2000.
"Next time, hopefully I can keep my cool a little better and focus in on the task at hand."
Briton Andy Murray and doubles partner Eric Butorac were beaten 6-4 6-4 in the second round by Richard Gasquet and Robert Lindstedt.