Andy Murray has admitted defeat in his battle to be fit for the French Open and has also raised doubts about his preparations for Wimbledon.
Murray picked up the injury during a match against Filippo Volandri
Murray sustained a wrist injury at the Hamburg Masters last week and it has not healed in time for Roland Garros.
Murray told his website: "I saw the doctor yesterday and as I expected I'm going to have to withdraw.
"The good news is I got the cast off and will start treatment tomorrow and take it day by day."
I'm not going to make any decisions on the grass yet
Murray suffered the injury in the first round at Hamburg, when leading Filippo Volandri 5-1.
X-rays showed he had not broken any bones but his wrist was inflamed and he was forced to wear a cast.
Wimbledon gets under way on 25 June, with Murray due to play at the Stella Artois tournament at Queen's from 11 June.
But he added: "I'm not going to make any decisions on the grass yet.
"I'm going to see the doctor in a week to see how it feels, and how much the inflammation has settled.
"One real positive from the injury is that I can get in the gym six days a week and work on my cardio and my leg strength."
Murray has slipped one place in the latest world rankings, from 10th to 11th.
But new number 10 Tommy Haas has also pulled out of the Roland Garros event, with an injured right shoulder.