By Sarah Holt
BBC Sport at Wimbledon
Unseeded Serbian Janko Tipsarevic dumped fifth seed Fernando Gonzalez out of Wimbledon after claiming a thrilling see-saw battle 6-3 3-6 6-3 4-6 8-6.
Tipsarevic's previous best at Wimbledon was the third round in 2005
Tipsarevic was two sets to one up before a rain delay in the fourth came to Gonzalez's rescue - and when play resumed the Chilean levelled the match.
But Tipsarevic, 23, hit back from 5-2 down in the decider and saved a match point at 5-6 before prevailing.
Third seed Andy Roddick beat Fernando Verdasco in the day's final match.
Tipsarevic now faces Juan Carlos Ferrero, who beat him at last year's Australian Open, after the Spanish 20th seed's surprise win over ninth seed James Blake.
The Serb was given a standing ovation by the Centre Court crowd after posting his first win over a top 10 player.
"Ever since I was a kid, my dream was to win matches on Centre Court at Wimbledon because for me this is the most special tournament in the world," he said.
Ever since I was a kid, my dream was to win matches on Centre Court
"I think the crowd loves a fight. The crowd loves to see someone competing with the number five in the world."
Ferrero triumphed 3-6 6-3 6-3 7-6 (7-4) to reach the fourth round for the third time in his career.
It means Blake has failed to progress beyond the third round in his five visits to the Championships.
"Obviously right now I'm disappointed and I think about the things I could have done," he said.
"But he played exceptional tennis. He raised his game unbelievably in the second and third sets. He was confident. He was playing like when he was number one in the world."
Blake's defeat left Andy Roddick as the only surviving American in the men's singles, after the third seed's 6-3 6-4 7-6 (7-2) win over Fernando Verdasco.
The third seed broke once in each of the first two sets, in which he was comfortably the better player.
Verdasco, who reached the fourth round last year, woke up and broke to lead 2-0 in the third and quickly opened up a 5-2 lead to boost hopes of a revival.
Roddick was runner-up in the 2004 and 2005 Championships
But some unforced errors and blistering Roddick returns let the third seed back in and he went on to win the tie-break.
Roddick admitted he was relieved to complete his late-night victory at just before 2100 BST - nearly two hours after the match had started.
"It makes Saturday a lot less stressful and it is a bit of a relief," he said.
In round four Roddick faces Paul-Henri Mathieu, who had never previously been past the second round at SW19.
"Mentally I feel like I have a bit of an edge going in, although he has beaten some quality players in the first three rounds, with Radek Stepanek, David Ferrer and Ivan Ljubicic.
"They've all been pretty comfortable wins and that's quite a statement. I'm definitely aware that he's playing good tennis."
Mathieu's 4-6 7-5 6-2 6-3 win over 15th seed Ljubicic was not the only rood result for France on Friday.
Twelfth seed Richard Gasquet saw off compatriot Edouard Roger-Vasselin 6-3 6-4 6-2 while wildcard Jo-Wilfried Tsonga also advanced to the fourth round with a 6-3 7-6 (7-4) 6-3 win over Spain's Feliciano Lopez.