Mario Ancic came through a five-set marathon with Novak Djokovic to set up a quarter-final with Roger Federer.
Ancic was the last man to beat Federer on grass at Wimbledon in 2002
The eighth seed used his punishing serves to take the opener but Djokovic answered by winning the next two sets with some brilliant groundstrokes.
Ancic relied on his serve again to edge the fourth set and force the decider.
Djokovic immediately called for the trainer and Ancic was never in danger as he broke to win the match 6-4 4-6 4-6 7-5 6-3 in three hours, 24 minutes.
Ancic said his 31 aces were the major factor in the match and added: "I think I served really well today and had many aces. I was struggling with my returns but he served a big percentage.
"Court Two is much harder than the others, the ball bounces much higher so it was a little bit hard to adjust at the start.
"I'm looking forward to playing Federer and having another great match."
Sixth seed Lleyton Hewitt had to dig deep to see off Spaniard David Ferrer and reach the last eight.
In scorching heat on Court One, the Australian took the first two sets but could not shake off 23rd seed Ferrer.
The pair traded breaks in the third set before Ferrer snatched it 6-4 and then went a break up in the fourth set.
But the 2002 champion clawed the break back and then struck again for a 6-4 6-4 4-6 7-5 win and a last eight match with Marcos Baghdatis.
Hewitt said he was not surprised by the fighting spirit shown by Ferrer after battling to his four-set win.
"He's a tough competitor. I was pretty happy when I got two sets under my belt, but by no means did I think the job was done," said Hewitt.
"He keeps coming at you. He didn't let me play my best tennis but I had to find a way to win.
Nieminen celebrates his historic victory on Court Three
"Hopefully I can take the positives out of this against Marcos Baghdatis."
Jarkko Nieminen became the first Finnish man to reach the quarter-finals after a stormy 7-5 6-4 6-7 (2-7) 6-7 (6-8) 9-7 win over Dmitry Tursunov.
Nieminen lost two match points in the fourth set tie-break - the second after a 42-stroke rally.
And he won after a tense final set but both men were penalised by the umpire.
Tursunov was given a code violation while Nieminen lost a penalty point when his racket bounced out of court after he smashed it into the turf.
Nieminen had to climb over the backwall to collect the racket and had to apologise to the fans behind the court.
Tursunov was then involved in a finger-pointing exchange with the umpire as the players came off at the end of the match.
Jonas Bjorkman defeated doubles partner Max Mirnyi 6-3 7-6 4-6 2-6 6-3 to reach the Wimbledon quarter-finals for the second time in his career.
The 34-year-old Swede took the opener with some impressive play at the net and then came through a tense tie-breaker 8-6 for a 2-0 lead.
Bjorkman is in the Wimbledon singles for the 13th time
But Bjorkman suddenly seemed to wilt in the intense heat and the powerful Mirnyi took advantage to level the tie.
Just as quickly as he faded, Bjorkman came back to life in the decider and broke Mirnyi twice to triumph.
The Swede has now extended his head-to-head record over Mirnyi to 10-1.
Bjorkman and Mirnyi will put this result behind them when they team up in the third round of the men's doubles, where they are the number two seeds.
Radek Stepanek won a marathon match against Fernando Verdasco 6-7 (4-7) 6-3 4-6 6-4 6-2 to reach the first Grand Slam quarter-final of his career.
Stepanek, the 14th seed, was edged out in the first set tie-break but took the second set after winning the only break point.
Verdasco, fresh from his win over fourth seed David Nalbandian in round three, regained his advantage by winning the third set.
But Stepanek moved up a gear to win his second successive five-set match.