Tim Henman's Wimbledon 2005 campaign gets under way against Jarkko Nieminen of Finland on Tuesday.
The sixth-seeded Briton, four times a semi-finalist at the Championships, is second on Centre Court.
British interest actually began at 1200 BST when Andy Murray made his senior SW19 debut on Court Two.
Maria Sharapova begins the defence of her women's singles title while Andy Roddick and Justine Henin-Hardenne are also both in show-court action.
Henman, 30, is used to carrying the nation's expectations on his shoulders and is aiming to reach the second week of Wimbledon for the 10th year in a row.
"The first match in any tournament is never that easy, irrespective of the opposition, but I feel I've got a clear picture in my mind of what I want to try and do once I get out there, " Henman told his website.
"It's a tough opponent but I'm feeling good about my game.
"My grass court practice over the last week or so has gone well and I can't wait to get started at Wimbledon."
Murray has recovered from an ankle injury he picked up at Queen's a fortnight ago and will play George Bastl.
"There is maybe going to be a little bit of pain, but I think that is normal after a twisted ankle," said Murray, who practised on Monday with heavy strapping on his left ankle.
"That is not going to stop me from moving and running around 100%."
"It is one of the biggest tournaments in the world and I am going to be playing in it, so I am pretty chuffed," he said.
Bastl, 30, has spent much of his career on the Challenger circuit but hit the headlines when he beat Pete Sampras - also on Court Two - in five sets in 2002.
Aside from Henman and Murray, three other Britons - Jonathan Marray, Amanda Janes and Jane O'Donoghue - are in action on Tuesday.
In accordance with tradition, Sharapova will be the first match on Centre Court on the second day of the tournament.
The Russian second seed opens the defence of her Wimbledon crown against Nuria Llagostera of Spain.
French Open champion Henin-Hardenne faces a potentially tricky match against Elena Daniilidou of Greece on Court One, where Roddick opens proceedings against Jiri Vanek of the Czech Republic.
Last match on Centre Court features 19-year-old Rafael Nadal, whose sensational form on the men's tour this year saw him beat world number one Roger Federer on the way to winning the French title.
The Spaniard meets American Vince Spadea.