World number one Roger Federer battled past a spirited Marcos Baghdatis in Wednesday's night match at the US Open.
The Swiss star became the first man to reach the third round with a 6-2 6-7 (4-7) 6-3 6-1 victory.
Federer overwhelmed the 19-year-old Cypriot in the first set but let a lead slip in the second, before regaining his focus to wrap up the match.
The top seed will face Russian Dmitry Tursunov or France's 31st seed Fabrice Santoro in the last 32.
"I let him in the match and he took advantage of it," said Federer after his victory. "He took his chances
in the second set and surprised me with some of his shots.
"The match was almost too easy at the beginning and then all of sudden I was in a fight. Once I got my focus back in the third set he wasn't able to recover."
Fourth seed Lleyton Hewitt earlier breezed past Wayne Ferreira 6-1 7-5 6-4 in the first round.
Hewitt arrived at Flushing Meadows as a contender with a winning streak of 11 matches, while Ferreira was playing in his final Grand Slam event.
"When I get on a roll like I have been and I am winning more matches I feel more confident out there," said Hewitt after his victory.
"The last few weeks I have been playing as well as I ever have."
Fellow Australian Mark Philippoussis suffered a much worse day as he retired with a hip injury when trailing Nikolay Davydenko 6-1 3-6 6-3 6-7 (5-7) 1-4.
"It was a spasm or something," said Philippoussis.
"I couldn't push up on my serve. I've never had anything like this. I was feeling great out there. It came out of nowhere."
Eighth seed David Nalbandian, another player who has had his fair share of injury problems, began well with a 6-4 7-6 6-3 defeat of Dennis van Scheppingen.
The first surprise of the day came as former semi-finalist and 14th seed Fernando Gonzalez of Chile went down to Sweden's Robin Soderling 6-4 7-6 (7-3) 6-7 (4-7) 6-1.
And 20th seed Gustavo Kuerten followed Gonzalez out of the tournament, with former world junior champion Kristian Pless beating the Brazilian 6-4 3-6 6-1 7-6 (7-4).
In other first round matches, Sebastien Grosjean, seeded 12, fought past fellow Frenchman Olivier Patience 7-5 6-7 6-2 6-1, and Tommy Haas beat Davide Sanguinetti 6-1 5-7 6-2 3-6 6-2.