Marat Safin's dismal run continued with a first-round defeat to Thomas Enqvist at the US Open on Tuesday.
The 13th seed and former champion, who has not reached a final since April, went down 7-6 (7-5) 6-4 3-6 6-3 to 30-year-old Swede Thomas Enqvist.
"I've not got enough confidence to beat these guys at the moment," said Safin. "Coming to a tournament like this without any confidence is a bit tough.
"To be honest I'm not feeling very happy with myself."
In the showpiece night match on Athur Ashe Stadium Court, defending champion Andy Roddick completely outclassed 17-year-old compatriot Scoville Jenkins.
Roddick stormed to a 6-0 6-2 6-2 victory in just one hour 12 minutes to set up a tricky looking match with another 17-year-old, Rafael Nadal of Spain.
"It is going to be tough because (Nadal) likes to play the big
matches. I am going to have to force my game on him," Roddick said.
Along with Safin, Germany's Rainer Schuettler was another leading name to crash out and in even more surprising circumstances.
The 11th seed looked to be cruising as he took the first two sets against Andreas Seppi, but the Italian fought back for a stunning 3-6 4-6 7-6 (7-5) 7-6 (7-1) 6-1 victory.
Another shock looked possible on the Louis Armstrong Court when Tomas Zib took the first set against Juan Carlos Ferrero, who has struggled all season.
By the fourth set both players were firing on all cylinders and giving the crowd plenty to cheer about as Ferrero failed to serve out the match and was taken to a fifth.
But despite a succession of inspired shots from Zib, Ferrero rediscovered the form that won him the French Open last year as he came through 4-6 7-5 7-6 (8-6) 6-7 (4-7) 6-3 in four hours 29 minutes.
Olympic champion Nicolas Massu kept up the superb form that took him to gold in Athens with a crushing win over Jose Acasuso.
The Chilean, seed 10th, stormed to a 6-4 6-0 6-2 victory and meets Armenian Sargis Sargsian next.
Paradorn Srichaphan, the 15th seed, beat Victor Hanescu 4-6 6-4 6-1 6-1, but 24th seed Ivan Ljubicic retired injured against Hyung-Taik Lee.