Cazorla (left) helped Spain breach Lithuania's stubborn defence
By Alasdair Lamont
BBC Scotland in Salamanca
Spain will have to guard against a team determined to get their Euro 2012 campaign back on track and looking to claim the biggest scalp in the world.
That was the view of the Spanish midfielder Santi Cazorla ahead of his team's visit to Hampden on Tuesday.
He believes the Scots will want a big performance in front of their own fans.
"Everyone wants to win at home and beating the world champions has to be an extra motivation for Scotland," the Villarreal player told BBC Scotland.
"They'll want to show they can match us, with the home crowd behind them.
"Everyone wants to qualify and Scotland are no different."
We'd expect Scotland to try to impose their game on us, meaning we'll have to play really well to take the three points
Spain midfielder Santi Cazorla
Cazorla admitted that Darren Fletcher was one of the few Scotland players he knew of but stressed that would not mean Spain could afford to take the home side lightly.
"Fletcher is one of the better-known players, but I think what we have to be wary of is the team as a group, more than any individuals," he said.
"They'll be strong collectively and therefore difficult to beat.
"I know there will also be a terrific atmosphere and playing away from home in that kind of environment always makes winning more tricky.
"We'd expect Scotland to try to impose their game on us, meaning we'll have to play really well to take the three points, but we have enough belief in our ability to be able to do just that."
Scotland coach Craig Levein was criticised for being ultra-defensive in their 1-0 defeat by the Czech Republic but is hinting at a more positive approach on Tuesday.
"I don't know how the Scots will approach Tuesday's game," said Cazorla.
"Certainly, Lithuania played very defensively against us, with plenty of men behind the ball, and that usually makes it more difficult to find a way through.
"But we kept pushing and finally got the breakthrough - and hopefully we can do the same in Glasgow, if that's what it takes."
Spain lead Group I with a 100% record after two games, two points ahead of Scotland with a game in hand.
Athletic Bilbao striker Fernando Llorente scored twice as Spain beat Lithuania 3-1 on Friday but said: "It's probably going to be more complicated because Scotland close the game down at the back.
"That'll make it more difficult to score against them, but hopefully we can play well and win."
It took Spain - and Llorente - until the second minute of the second half before their pressure was finally rewarded with a goal in Salamanca.
And Llorente knows there could be a similar pattern to the match at Hampden.
"We had to work hard to get the goals because Lithuania defended very well, we hit the post and missed quite a few good chances," he said.
"We hope Scotland don't have the good fortune Lithuania had and that we're more clinical, particularly at the start of the match."
Llorente's double against Lithuania means he now has six international goals in just 11 appearances and he is determined to make the most of his opportunities in Vicente del Bosque's side, in the continued absence of Fernando Torres.
"Of course I'd like to score again against Scotland, to help the team," he added.
"I've never been in Scotland, so I don't know Hampden Park at all, but I'm looking forward to playing there."