Cardiff Blues flanker Williams is preparing to win the 86th cap of an international career that stretches back to 1996.
He made an abortive attempt at retirement after the 2007 World Cup, only to be lured back by coach Warren Gatland, who hopes to nurse the Pontypridd product through to challenge for the William Webb Ellis Trophy in 2011.
"Martyn Williams is a very astute player who seems to be getting better with age and needs to be countered by our whole team," said Johnson, who will hope that the bigger and more abrasive Worsley can rough up his opposite number.
"He is a key player for Wales, he is a very good player.
"I remember him coming on the 2001 Lions tour. He has still got all the skills and mentally he still has the know-how from experience.
"He is a great link man with off-loads and passes. He is very dangerous.
"He was talking about retiring after the 2007 World Cup. I am happy to see him playing well and being successful - just not this Saturday."
Worsley will make his first England start since the 2007 World Cup
Williams, who captained Wales to their opening 26-13 Six Nations success against Scotland in the injury absence of Ryan Jones, has played against Worsley many times, but never with the England man in the number seven shirt.
"He's such a great athlete that he can play anywhere across the back row," said Williams.
"He's a quality player who has been there, done it, and was part of the  World Cup-winning squad. He's a tough player, a real warrior.
"[But England have] a lot more to worry about in the Wales team than me.
"The reason we were so good at the breakdown last week was because we were on the front foot.
"Our backs were getting over the gain line and our front five were doing a great job so it makes the back-row's job a lot easier."
Johnson admits to 'underdogs' tag
Of the 117 encounters between the old rivals, Wales have won 52 times while England have been successful 53 times. There have been 12 draws.
Wales are seeking a hat-trick of Six Nations wins against England for the first time and have been installed as 1/5 favourites, but it is a tale of success against the old enemy that is unfamiliar to Williams in his 13-year international career.
"It's probably the first time we've been favourites, maybe we were in 2005," said Williams, who is seen as one of the few players in the Wales team without a stand-out successor.
Being favourites seem strange to me, but a lot of the younger boys have had a lot of success and are wondering what all the fuss is about
"But just look at the names on the England team-sheet - they've all been there and done it. They've been criticised all week and have plenty of motivation."
Williams was part of Kevin Bowring's Wales side that crashed to a record 60-26 loss to England at Twickenham during a dire losing streak in 1998.
"I can't sum up everything that has changed since then," said Williams.
"They [England] were so much more professional than us off the field. Now there's more of a level playing field, that's where the main changes have happened.
"Being favourites seem strange to me, but a lot of the younger boys have had a lot of success and are wondering what all the fuss is about international rugby.
"We try to keep reminding them that it's not as easy as it seems at the moment.
"A lot of us know about the bad times and don't want to go back there.
"We've got a great balance in the squad, it's a great place to be at the moment and we hope to keep it that way."
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