Dragons prop Adam Black said he was ready for the challenge of facing three-time winners Toulouse.
"It's a pretty tough draw which reflects the intensity of the tournament in Europe," Black told the Dragons website.
"This is the kind of intensity that we relish here at the Dragons and I'm sure we can be more competitive in the coming season.
"I am looking forward to the experience, skill and energy that the new signings will bring to the squad."
Llanelli Scarlets team manager Garan Evans had mixed emotions about the task awaiting his side.
"It could have been better, but it could have been worse," he told the Scarlets website.
"We can look forward to going to Paris, we haven't played Stade Francais for some time so that will add something exciting and different.
"Harlequins will be in the same boat and we know all about Ulster.
"If you look at all the groups they are all pretty competitive so I think the new seeding system in place has worked pretty well.
"If you look at the history of the draw there have been some pretty poor groups, but that's not the case this time round."
Blues director of rugby Dai Young also felt that the seeding system had delivered a fair result.
"We did fear the worst being seeded third but I think this season's draw has given us a chance," he told the Blues website.
We have to be confident of improving on last year's showing and progressing past the quarter finals for the first time
Ospreys lock Alun Wyn Jones
"It is not the hardest group that we have had, but Biarritz is never an easy place to go and get a result, Gloucester is one of the biggest fortresses in English rugby and Calvisano is also a difficult place to go to.
"Overall I'm pleased with the draw. You have got to win your home game and try to get something on the road."
Ospreys lock Alun Wyn Jones said his side will look forward to a rematch with Leicester, who they beat in this year's EDF Energy Cup final.
"We've played them in each of the last three seasons," said the Wales star.
"Like us they will go into the competition with a new coach, so while their players will be up for it after we beat them at Twickenham, the matches will have a different complexion.
"Perpignan have gone all the way to the final before and reached the knock-out stages last season, so we know that we'll have to be on the top of our game if we are to win the group, but I think its definitely achievable.
"We got through to the quarter finals as best runners-up last season when I think it was there for us to win the group, so I can't see why we can't go one better this time around.
"If we do that, we have to be confident of improving on last year's showing and progressing past the quarter finals for the first time."
The draw was the first to use the new European Rugby Cup rankings system which split the clubs into four tiers based on performances in the competition over the last four seasons.
Teams from the same country were kept apart, but, with seven French clubs in the six pools, two of their sides - Clermont Auvergne, Montauban - are in Pool One.
Pool One: Munster, Sale, Clermont Auvergne, Montauban Pool Two: Wasps, Leinster, Castres, Edinburgh Pool Three: Leicester, Perpignan, Ospreys, Treviso Pool Four: Stade Francais, Llanelli Scarlets, Ulster, Harlequins Pool Five: Toulouse, Bath, Newport Gwent Dragons, Glasgow Pool Six: Biarritz, Gloucester, Cardiff Blues, Calvisano
Round One: 10-12 October
Round Two: 17-19 October
Round Three: 5-7 December
Round Four: 12-14 December
Round Five: 16-18 January
Round Six: 23-25 January
Quarter-finals: 10-12 April
Semi-finals: 1-3 May
Final: 22-24 May (Murrayfield)
*Fixtures, dates and times are subject to late change
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