Australia 31 (6)
Wing Digby Ioane added a try to his first cap for Australia
Tries: Ioane, Mitchell, Huxley.
Cons: Mortlock 2.
Pens: Mortlock 4.
Wales 0 (0)
Wales were humbled in Brisbane as Australia launched a fierce second-half onslaught to boss the second Test.
The Wallabies ended a first half, only notable for a bad injury to Wales wing Chris Czekaj, just ahead with Stirling Mortlock kicking two penalties.
But Digby Ioane brought the game alive after half-time as the Western Force wing raced away for a try on debut.
Fellow wing Drew Mitchell also scored from a swift counter-attack, with Julian Huxley completing the rout.
After losing the first Test in Sydney 29-23 to a last-gasp try, Wales had high hopes of claiming a rare win in Australia at the Suncorp Stadium.
But after a poor opening period the tourists had little answer as Australia at last stopped dropping passes in the backs to run them ragged.
Number eight Wycliff Palu, notably, punched gaps through the Welsh defence seemingly at will.
Training injuries had forced Wales to select Ceri Jones at tight-head, rather than the Harlequins prop's preferred loose-head role.
But there was no sign of any creaking from the Wales tight unit at the early scrummages as the tourists held firm.
The men in red were also flying into the tackle in open play, but Matt Giteau opened Wales up with a classy inside ball to send Nathan Sharpe through midfield.
Mortlock was sent into space down the left wing, but Sonny Parker was across quickly with a tackle that forced the Wallaby captain to knock-on.
The danger seemed to have been averted but Jon Thomas allowed himself to get isolated as he drove off the back of a scrum, holding on to concede a penalty that Mortlock kicked.
Wales should have been level within two minutes, but James Hook - who struggled with his place-kicking in last week's loss in Sydney - missed a relatively straight-forward chance.
A second Mortlock penalty after 18 minutes, again forced by good scavenging work at the breakdown, doubled the Australian lead before Wales were forced into an early change.
Blues wing Chris Czekaj was stretchered off after suffering a suspected dislocated kneecap in a tackle by Stephen Moore, with Gavin Henson coming on at full-back and Gareth Thomas switching to the wing.
More woe followed for Wales as centre Jamie Robinson limped off to be replaced by Ceri Sweeney.
The injury disruptions did not help the flow of what was already a scrappy game, the line-out a particular problem, while referee Paul Honiss fussed away what little life remained in the first half.
Wales wing Chris Czekaj suffered a worrying leg injury
Australia coach John Connolly sent on George Gregan for the second period, hoping the veteran scrum-half could exert some control on proceedings.
Giteau moved into the centre, Adam Ashley-Cooper making way, while Adam Freier came on at hooker to try and solve the line-out problems.
The rewards were immediate as Mortlock stroked over his third penalty, before the Wallabies at last discovered some slickness to claim the game's first try.
Wales wing Aled Brew, winning his second cap, just failed to intercept a pass but the miss left Australia with a four-man overlap on the right.
Mike Phillips and Henson flew in but the numbers told against the Welsh tacklers as Ioane loped clear down the wing for a try on debut.
Mortlock missed the conversion, spoiling his 100% record for the night, but the Wallabies were up and running.
Mitchell was pulled down just short of the Welsh line after stepping inside Gareth Thomas.
But Wales stole the ball to launch a counter-attack through Hook that carried the tourists into Australian territory for the first time after the restart.
A break by Phillips suggested Wales had also caught the more adventurous mood, but a fourth Mortlock penalty stretched the hosts' lead to 17-0.
Any lingering hopes of a Welsh comeback were finally extinguished as Australia turned over possession, Stephen Larkham sending Mitchell racing away down the left wing for a converted try.
Wales were looking ragged and Brumbies full-back Huxley soon claimed a third try, chipping over a flat defence to claim another seven-pointer.
Blues forward Scott Morgan came on to win his first cap, while Colin Charvis was held up over the line as he tried to prevent Wales being 'nilled' for the first time since 1998.
But Wales will now take their weakened squad back home to prepare to take on the Wallabies in their World Cup pool clash in Cardiff on 15 September.
Australia: Julian Huxley (ACT); Digby Ioane (WF), Stirling Mortlock (ACT, capt), Adam Ashley-Cooper (ACT), Drew Mitchell (WF); Stephen Larkham (ACT), Matt Giteau (WF); Benn Robinson (NSW), Stephen Moore (QLD), Guy Shepherdson (ACT), Nathan Sharpe (WF), Dan Vickerman (NSW), Rocky Elsom (NSW), George Smith (ACT), Wycliff Palu (NSW).
Replacements: Adam Freier (NSW), Matt Dunning (NSW), Mark Chisholm (ACT), Stephen Hoiles (ACT), Phil Waugh (NSW), George Gregan (ACT), Mark Gerrard (ACT).
Wales: Gareth Thomas (Blues, capt); Chris Czekaj (Blues), Jamie Robinson (Blues), Sonny Parker (Ospreys), Aled Brew (Ospreys); James Hook (Ospreys), Mike Phillips (Ospreys); Iestyn Thomas (Scarlets), Mefin Davies (Leicester), Ceri Jones (Harlequins), Michael Owen (Dragons), Robert Sidoli (Blues), Colin Charvis (Dragons), Gavin Thomas (Scarlets), Jonathan Thomas (Ospreys).
Replacements: Richard Hibbard (Ospreys), Chris Horsman (Worcester), Scott Morgan (Blues), Robin Sowden-Taylor (Blues), Andy Williams (Dragons), Gavin Henson (Ospreys), Ceri Sweeney (Dragons).
Referee: Paul Honiss (New Zealand).