Duncan Jones will captain new Wales coach Gareth Jenkins' first squad for the two-Test tour to Argentina in June.
Wales coach Gareth Jenkins has picked Duncan Jones as captain
The Ospreys prop, 27, has won 27 caps since making his debut in 2001.
Jenkins has opted to rest several senior players, including Stephen Jones, Robert Sidoli, Rhys Thomas, Martyn Williams and Michael Owen.
With another 12 capped players left out due to injury or rehabilitation, including last season's skipper Gareth Thomas, Wales have a youthful look.
The likes of Lions Dwayne Peel, Brent Cockbain and Ryan Jones were also overlooked due to injury in the 28-man squad.
Like the new captain, four of the five uncapped players are also Ospreys, with fly-half James Hook joining locks Ian Evans and Alan Wyn Jones, plus hooker Richard Hibbard.
The Newport Gwent Dragons provide the other Test rookie in the shape of prop Rhys Thomas.
However, there is still plenty of experience with the likes of Lee Byrne, Shane Williams, Mark Jones, Hal Luscombe and Gavin Henson in the backs.
Henson has been named as a centre, leaving fly-half Nick Robinson and Cardiff Blues colleague Mike Phillips as the likely starting half-backs.
Touring sides to Argentina always face a tough examination up front.
Apart from Blues hooker Rhys Thomas, Jenkins has opted to take the front row which played in the Six Nations under predecessors Mike Ruddock and Scott Johnson.
Pumas coach Marcelo Loffreda has a full squad to choose from
Dragons pair Luke Charteris and Ian Gough join the two Ospreys youngsters at lock, while the back row features Gareth Delve, Dafydd Jones, Alix Popham, Robin Sowden-Taylor and Gavin Thomas.
There is no place for 84-times capped former Wales skipper Colin Charvis, who is out of contract with Newcastle Falcons at the end of the season.
Two other veterans left out are Gloucester hooker Mefin Davies and Scarlets captain Dafydd James.
"I have spoken to Colin, Dafydd and Mefin and these players we know plenty about," said Jenkins.
"We know them inside out and they have an opportunity to rest and recharge themselves."
Argentina are expected to be near full-strength, with Pumas coach Marcelo Loffreda naming a squad that includes all his overseas stars.
Wales are likely to face the attacking flair of Agustin Pichot, Felipe Contepomi and Ignacio Corleto, plus the brute forward force of the likes of Ignacio Fernandez Lobbe, Juan Manuel Leguizamon, Omar Hasan, Mario Ledesma and Rodrigo Roncero.
The Pumas play Wales on 11 June in Puerto Madryn, Patagonia, and on 17 June in Buenos Aires, before welcoming New Zealand to the capital on 24 June.
Wales squad: Full back: Lee Byrne (Scarlets). Wings: Chris Czekaj (Blues), Shane Williams (Ospreys), Mark Jones (Scarlets). Centres: Jamie Robinson (Blues), Hal Luscombe (Dragons), Matthew Watkins (Scarlets), Gavin Henson (Ospreys). Outside-halves: James Hook (Ospreys), Nicky Robinson (Blues). Scrum-halves: Mike Phillips (Blues), Andy Williams (Bath). Props: Duncan Jones (Ospreys, capt), Gethin Jenkins (Blues), Adam Rhys Jones (Ospreys), Rhys Thomas (Dragons). Hookers: Huw Bennett (Ospreys), Richard Hibbard (Ospreys), Matthew Rees (Scarlets). Second rows: Luke Charteris (Dragons), Ian Evans (Ospreys), Ian Gough (Dragons), Alun Wyn Jones (Ospreys). Back rowers: Gareth Delve (Bath), Dafydd Jones (Scarlets), Alix Popham (Scarlets), Robin Sowden-Taylor (Blues), Gavin Thomas (Scarlets).
Argentina squad: R Alvarez Kairelis (Perpignan), M Ayerza (Club Newman), L Borges (Stade Francais), R Carballo (Toulon), M Carizza (Biarritz), F Contepomi (Leinster), I Corleto (Stade), M Durand (Montpellier), I Fernandez Lobbe (Sale), JM Fernandez Lobbe (Liceo Naval), N Fernandez Miranda (Hindu Club), P Gambarini (CASI), O Hasan (Toulouse), JM Hernandez (Stade), M Ledesma (Clermont), JM Leguizamon (L Irish), F Leonelli (Edinburgh), G Longo Elia (Clermont), FM Aramburu (Biarritz), JM Nunez Piossek (Bayonne), L Ostiglia (Agen), A Pichot (Stade), R Roncero (Stade), M Scelzo (Clermont), G Tiesi (L Irish), F Todeschini (Beziers).