England 111-13 Uruguay
Tries: Moody, Lewsey (5), Balshaw (2), Catt (2), Gomarsall (2), Luger, Abbott, Robinson (2), Greenwood
Cons: Grayson (11), Catt (2)
Pen: Menchaca (2)
Josh Lewsey ran in five tries as England confirmed their mastery of Pool C with a predictable, yet impressive, demolition of Uruguay.
But England's highest-ever World Cup score was marred by an injury to wing Iain Balshaw, who was stretchered off in the second half with a sprained ankle.
Clive Woodward's side enjoyed a comfortable warm-up for the knock-out stages as they ran in 17 tries in what was always going to be a mismatch.
They can now look forward to a quarter-final meeting with Wales in Brisbane next Sunday, after their Six Nations rivals lost 53-37 to New Zealand in Sunday's other game.
England had already made several assaults on the Uruguay line by the time Lewis Moody went in on the right for their first try in the third minute.
But instead of throwing open the floodgates, England were initially hampered by the kind of errors that had taken the gloss off their march to victory in Pool C.
Juan Menchaca cut the deficit for Uruguay with a penalty in front of the posts, and missed the chance to make it 6-7 with another kick which drifted just wide.
England finally hit form with three scores in the space of four minutes, full-back Lewsey slipping a tackle to go over down the blind side and Balshaw crossing twice in quick succession.
After getting in some solid defensive practice by weathering a sustained assault on their line, England scored their best try so far.
A flowing move involving Balshaw and Lewsey culminated in a score for Mike Catt, and a try from Gomarsall gave England a 42-6 half-time lead, with a further Menchaca penalty the only consolation for Uruguay.
The tries continued to flow after the break.
Lewsey ran in his second after excellent work from Joe Worsley, and Dan Luger opened his account.
Woodward decided to give big guns Martin Johnson and Jason Robinson some game time, but there was concern when Balshaw was stretchered off with an ice pack on his ankle after falling awkwardly in a tackle.
Woodward, however, said after the game that he expected Balshaw to be fit for the quarter-final.
Uruguay were rewarded for refusing to throw in the towel soon after when prop Pablo Lemoine crashed over from close range and Menchaca converted.
But normal service was resumed when Stuart Abbott jinked his way through to touch down, before Lewsey completed his hat-trick as England continued to run from all over the pitch.
Robinson touched down twice either side of further scores from Lewsey and Gomarsall as Uruguay's resistance crumbled, before Will Greenwood marked his return from a trip home to see his pregnant wife with the most popular try of the night.
Catt's second brought up a century of points before Lewsey scored his fifth to equal England's individual try-scoring record.
Worsley blotted his copybook late on by being sent to the sinbin for a needless high tackle.
England: J Lewsey; I Balshaw, S Abbott, M Catt, D Luger; P Grayson, A Gomarsall; P Vickery (capt), D West, J Leonard; D Grewcock, M Corry; L Dallaglio, L Moody, J Worsley.
Replacements: S Thompson, J White, M Johnson, B Kay, K Bracken, W Greenwood, J Robinson.
Uruguay JM Menchaca; J Pastore, D Aguirre (capt), J De Freitas, J Viana; S Aguirre, J Campomar; E Berrutti, D Lamelas, P Lemoine, J-C Bado, J-M Alvarez, N Brignoni, N Grille, R Capo.
Replacements: JA Perez, R Sanchez, G Storace, J Alzueta, M Guttierrez, E Caffera, D Reyes.