All the action from the Pool C match in Perth.
80 mins: Uruguay launch one final attempt at scoring a try but number eight Rodrigo Capo is bundled into touch, prompting referee Paddy O'Brien to blow his whistle for the final time.
FT: S Africa 72-6 Uruguay
76 mins: Hougaard launches a chip ahead to the line and Werner Greef outsprints the Uruguay defence to dot down for a 12th try for South Africa. Hougaard is again unable to convert.
S Africa 72-6 Uruguay
73 mins South Africa win a line-out close to the Uruguay line and Scholz, who has only just come on, is on the end of the drive for the 11th try. Hougaard misses the conversion.
S Africa 67-6 Uruguay
71 mins: The Springboks bring on their final replacement, flanker Hendro Scholtz.
67 mins: South Africa punish a tiring Uruguayan defence with their ninth try, lock Bakkies Botha sprinting in under the posts for his second score. Derick Hougaard adds the conversion.
S Africa 62-6 Uruguay
63 mins Hougaard makes an instant impression when he collects a short tap penalty and sneaks through a gap to the line, but the television official rules he has failed to apply sufficient downward pressure.
60 mins: South Africa give van der Westhuizen and Koen a rest, bringing on replacement half backs Neil de Kock and Derick Hougaard.
58 mins: The Springboks are rampant now and another wave of attacks sees Joost van der Westhuizen sniping over to complete a hat-trick of tries. Koen misses the conversion.
S Africa 55-6 Uruguay
54 mins: South Africa score their eighth try through impressive flanker Danie Rossouw, who barges through three weak tackles before stretching over. Koen brings up the half-century.
S Africa 50-6 Uruguay
52 mins: The Springboks win a line-out 15 metres out and prop Richard Bands sprints through to score the opening try of the second half. Louis Koen adds the conversion.
S Africa 43-6 Uruguay
48 mins: South Africa wing Ashwin Willemse appears set to score in the right corner but is cut down with a superb tackle from Joaqui Pastore.
44 mins: Uruguay bring on two of their best players in flanker Nicolas Grille and full-back Juan Ramon Menchaca, who both joined the squad late due to work commitments.
42 mins: Uruguay have an early opportunity to get more points on the board but Diego Aguirre sends his penalty attempt wide.
1402 BST: Uruguay kick off the second half.
40 mins: Referee Paddy O'Brien blows his whistle to signal half-time.
HT: S Africa 36-6 Uruguay
39 mins: Diego Aguirre lines up a third penalty attempt for Uruguay but this time sends his effort wide of the left upright.
36 mins: Debutant centre Jacque Fourie picks up the ball inside his own half, cuts across field and sets off on an arcing run all the way to the right corner for a sixth Springbok try. Koen converts with a drop kick.
S Africa 36-6 Uruguay
31 mins: South Africa win a line-out on the right touchline and spread play across the backline to send wing Thinus Delport over in the left corner. Koen is again unable to add the extras.
S Africa 29-6 Uruguay
27 mins: Uruguay full-back Joaqui Pastore fluffs a clearance kick and South Africa launch a wave of attacks which finish with lock Bakkies Botha crashing over for a fourth try, securing a bonus point in the process. Koen misses the conversion.
S Africa 24-6 Uruguay
24 mins: South Africa lock Victor Matfield is penalised for coming in from the side of a ruck and Aguirre drills over a second confidently-struck penalty for the underdogs.
S Africa 19-6 Uruguay
21 mins: Uruguay stem the tide and captain Diego Aguirre lands their first points with a penalty.
S Africa 19-3 Uruguay
18 mins: A midfield break from De Wet Barry cuts open the Uruguay defence and van Niekerk acrobatically takes a pass from fellow back-rower Danie Rossouw to score a third South African try. Louis Koen adds the conversion.
S Africa 19-0 Uruguay
14 mins: Uruguay lose a line-out on their own throw as the impressive Joe van Niekerk steals the ball and launches another Springboks attack.
11 mins: Koen launches a high kick to the left corner but wing Thinus Delport is unable to gather as Uruguay full-back Joaqui Pastore reaches the ball first.
5 mins: Van Niekerk and wing Ashwin Willemse make inroads into the Uruguay defence before van der Westhuizen bursts through to extend his South Africa try-scoring record to 37 with a second try. This time Koen is on target with the conversion.
S Africa 12-0 Uruguay
1 min: The game gets off to an explosive start as Springboks flanker Joe van Niekerk breaks off the back of a ruck and slips a pass inside for scrum-half Joost van der Westhuizen to score the opening try. Koen misses the conversion from the touchline.
S Africa 5-0 Uruguay
1306 BST: South Africa fly-half Louis Koen kicks off.
1300 BST: Uruguay run out onto the Subiaco Oval with nine of the players that lost to South Africa in the 1999 World Cup.
The Springboks are giving debuts to centre Jaque Fourie and flanker Danie Rossouw.
South Africa: W Greeff; A Willemse, J Fourie, DW Barry, T Delport; L Koen, J VD Westhuizen (capt), L Sephaka, D Coetzee, R Bands, B Botha, V Matfield; J van
Niekerk, D Rossouw, J Smith.
Replacements: J Smit, F Rautenbach, S Boome,
H Scholtz, N Kock, D Hougaard, R Loubscher.
Uruguay: J Pastore, A Cardoso, D Aguirre (capt), M Mendaro, E Ibarra; S Aguirre, E Caffera; R Sanchez, D Lamelas, P Lemoine; J Alzueta, JC Bado; N Brignoni, M Guttierrez, R Capo.
Replacements: E Berruti, JA Perez, G Storace, N Grille, H Ponte, B Amarillo, JR Menchaca.