Saint-Andre has also coached Gloucester and French club Bourgoin
Sale have announced director of rugby Philippe Saint-Andre will join French club Toulon on 1 July.
The former France international will be replaced by current head coach Kingsley Jones, who will immediately assume Saint-Andre's responsibilities.
Jones had been primed to take over at the end of the season, but Sale are keen to promote him while Saint-Andre remains a part of the coaching staff.
Sale hooker Sebastien Bruno will also follow Saint-Andre to Toulon.
Former Gloucester coach Saint-Andre, who led Sale to their only Premiership title in 2006, announced last month he would be leaving Edgeley Park at the end of season.
He had been linked with several clubs in France, but opted for the challenge of struggling Toulon, where he will become the director of sport.
The big-spending club, currently second from bottom in France's Top 14 league, are managed by former New Zealand captain Tana Umaga, who is set to resume his playing career in a bid to avoid relegation.
The 79-timed capped All Black led Toulon to promotion from the second division last season, but has seen his side struggle in the current campaign, despite the high-profile acquisitions of Sonny Bill Williams, Jerry Collins and Joe van Niekerk.
"I've found the mastermind - Philippe Saint-Andre, who will be sporting director in charge notably of recruitment and sporting structures," said ambitious Toulon owner Mourad Boudjellal. "He will work in close collaboration with manager Tana Umaga."
Former Wales captain Jones said he was delighted that Saint-Andre will still be involved in the coaching set-up for the current campaign.
"I know that Philippe wants to win the Guinness Premiership as much as anybody at the club and his experience and rugby knowledge will be invaluable to us as we attempt to win our second Guinness Premiership," he said.