Ben Foden claimed a hat-trick while Hodgson landed 10 from 11 kicks
Sale (25) 67
Tries: Schofield, Foden 3, Fernandez Lobbe, Bell, Chabal, Robinson, Mayor
Cons: Hodgson 8
Pens: Hodgson 2
Calvisano (8) 11
Pens: Marigny 2
Sale bounced back from their opening Heineken Cup loss to Ospreys to rout Calvisano with a flurry of late tries.
Charlie Hodgson, who kicked 22 points, landed two penalties before lock Dean Schofield was driven over, Ben Foden's quick-fire brace making it 25-0.
Roland De Marigny hit back with a try and two penalties for the Italians.
But Foden completed his hat-trick before Ignacio Fernandez Lobbe, Chris Bell, Sebastien Chabal, Jason Robinson and Chris Mayor all crossed late on.
It was only 32-11 with 10 minutes remaining but the Sharks took full advantage of the tiring visitors to pile on the tries, which may prove crucial in what should be a tight pool.
Foden, normally a scrum-half but deputising for the injured Mark Cueto on the wing, showed the way with a clinical display of finishing.
Calvisano arrived in Stockport without a Heineken Cup victory in four years, and despite their defiance before the interval, there was never any chance of that sequence ending.
The Sharks used their bench to good effect late on to put themselves in good heart for the potentially decisive double-header with group favourites Stade Francais in December.
Sale stand-off Charlie Hodgson told BBC Radio Manchester:
"They were a physical side and made life hard for us but fortunately the boys stuck at it and our fitness showed.
"It was good to rack up the scores in the end. Our aim was to bounce back from last week, get the bonus point and score as many tries as possible, because it might come down to tries scored in this group."
Sale director of rugby Philippe Saint-Andre on Ben Foden:
"Ben is going to be a fantastic player and he took his tries fantastically well. He was outstanding on the wing and then at scrum-half.
"We thought we could score a few tries in the last 10 or 15 minutes and so it proved. There were some fantastic tries."
Calvisano's former Sale wing Warren Spragg:
"It was nice to come back and play where I started out. We lost it a bit in the last 10 minutes but I thought we put on a good show against one of the best teams in Europe."
Calvisano coach Marc Delpoux:
"In the last 20 minutes they were just too powerful for us and that showed with the tries they scored.
"But I'm pleased with the way the players dug in and we can be proud of our efforts."
Sale: Larrechea; Foden, Mayor, Bell, Hanley; Hodgson,
Wigglesworth; Sheridan, Goana, Stewart; Schofield, Day; White, Lund, Chabal.
Replacements: Robinson for Larrechea (58), Roberts for Sheridan (69), Titterrell for Goana (47), Turner for Stewart (72), I. Fernandez Lobbe for Schofield (40), Jones for Day (63).
Calvisano: Maringy; Gallinetti, Downey, Zanoletti, Spragg; Scanavacca, Griffen; Bocca, Intoppa, Cittadini; Purll, Gissing; Ngauamo, Persico, Zanni.
Replacements: Pastormerlo for Scanavacca (37), Zaffri for Cittadini (40), Bernabo for Ngauamo (53), Patelli for Persico (53), Dal Maso for Zanni (56).
Not Used: Ghiraldini, Moore.
Sin Bin: Downey (30).
Referee: R Poite (RFU).