Quins chief executive Mark Evans suggested in an open letter on 12 August that some supporters may feel that the "manipulation of the substitution, uncontested scrums and sin-binning rules are so widespread in the game that this case has been blown out of all proportion".
Former England hooker and current Leicester coach Richard Cockerill has claimed he had stitches in a finger wound opened up while on international duty to facilitate a blood substitution.
And ex-England coach Dick Best said in 2001 that fake blood was "in common use" in the Premiership.
But Worsley insists that those suggestions do not match his experience.
"If they thought about the tiny gains they could make by doing what they did compared to the drastic consequences it's a no-brainer," he said.
Quins 'blood' scandal not uncommon - Skinner
"You just wouldn't do it. Now people have seen the consequences, I'm sure no-one is going to risk doing it."
Harlequins could face further punishment from the Rugby Football Union for the incident, which occurred against Leinster at the quarter-final stage of last season's Heineken Cup.
The RFU may take action after receiving details of organisers European Rugby Cup's appeal against punishments for Quins' former head coach Dean Richards, club doctor Wendy Chapman and team physiotherapist Steph Brennan.
Richards and Brennan received bans of three and two years respectively after initially having misconduct charges dismissed.
Harlequins and Wasps will kick off their Guinness Premiership campaigns against each other at Twickenham on 5 September.
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