Updates (all times BST):
80 mins: FULL-TIME Australia 49-0 South Africa
Latham kicks the ball to touch, the whistle goes and Australia celebrate a fine victory. The Boks must now regroup, and quickly, because they face reigning champions New Zealand next week.
79 mins: South Africa finally have a chance to gain a consolation after Tuqiri is penalised for a late shoulder charge on Bryan Habana after the ball has gone. They earn two line-outs near the Wallaby line but the first is lost while the second is not straight. The sloppy period of play optimises how poor they have been.
75 mins: TRY Australia 49-0 South Africa
The ball goes out near the halfway line and Rathbone takes it quickly to set up another attack. The Boks finally wake up and try to get back to cover but it is too late and after a neat interchange of passes, replacement lock Mark Chisholm touches down. Mortlock finds his range again and adds the two points.
73 mins: Yet another penalty is conceded by South Africa and Australia near the line. Again they bundle over but the Boks hold them up. South Africa have never failed to put points on the board against the Wallabies but they do not look like they will bother the scoreboard here.
66 mins: TRY Australia 42-0 South Africa
Australia go wide and again they look dangerous. Substitute wing Clyde Rathbone bravely kicks forward before he is bundled into touch and Giteau is in support to easily score. Mortlock misses the conversion.
65 mins: More subs from both sides as the game loses some of its intensity.
64 mins: South Africa knock on and from the resulting scrum, Cordingley easily breaks from the back to set up Nathan Sharpe but he is held up over the line. Fourie du Preez is the man who keeps the lock out.
62 mins: Latham cuts through a tiring South African defence and it looks as if the Wallabies will score again. However, the ball slips out and the attack breaks down.
58 mins: TRY Australia 37-0 South Africa
Cordingley looks to have scored but referee Paul Honiss rules that he is held up. Australia continue to attack and Giteau fires a cross-field kick to Tuqiri on the wing. He slips but is able to find Latham, who has the simple task of scoring Australia's fourth try. Mortlock converts.
55 mins: Both sides are making a host of changes. The main highlights include Paul going off injured for Australia and Akona Ndungane and Januarie making way for the Boks. Van der Westhuyzen stays on for now despite a dreadful game so far.
51 mins: South Africa are still deep in opposition territory but the home side keeps them out and force a couple of five-metre scrums. Australia are then able to clear when CJ van der Linde is pinged for not keeping his binding. The Australian scrum, so derided for the performances against England and New Zealand, is performing well.
49 mins: The Springboks are enjoying bit of possession and for once they threaten the Wallaby line. Skipper John Smit leads from the front and breaks a couple of tackles before feeding Montgomery who is held up inches from glory.
46 mins: Giant South African prop Os du Randt leaves the action with Eddie Andrews coming on.
43 mins: Australia immediately camp in the South Africa 22 but the visitors hold out and encouragingly for them force the error from Fava, who is penalised for holding on in the ruck.
41 mins: The rain starts to fall as Australia get the game underway. The home side have taken off captain Gregan with Sam Cordingley taking his place.
40 mins: HALF-TIME Australia 30-0 South Africa
The whistle goes and South Africa's nightmare half ends. Coach Jake White is sure to give his side a dressing down as his side's indiscipline, unforced errors and missed tackles are costing them dear. Australia, despite a shaky start, have steadied their scrum and look deadly out wide.
39 mins: Just to add to South Africa's misery, lock Danie Rossouw goes off injured and is replaced by Albert van der Berg.
37 mins: TRY Australia 30-0 South Africa
Centre Matt Giteau shows his worth to the team as he cuts a superb line to carve his way through South Africa's shambolic rush defence and cross unchallenged. Mortlock adds the two points. South Africa must be out of this game now.
31 mins: PENALTY Australia 23-0 South Africa
South Africa have made a catalogue of errors so far this half and Van der Westhuyzen makes another to put his side on the back foot again. His spill is kicked forward and Australia spread the ball wide but as South Africa desperately try and get back, lock Victor Matfield bats the ball down from an offside position. He is sin-binned while Mortlock kicks for goal.
25 mins: TRY Australia 20-0 South Africa
George Gregan delivers a wonderful flat pass to release Larkham and the mercurial fly-half jinks his way through the Springbok defence. The ball goes inside and prop Greg Holmes supports to cross. Mortlock adds the extras.
21 mins: PENALTY Australia 13-0 South Africa
Springbok Percy Montgomery spills the ball in his own 22 to give Australia another opportunity. Flanker Joe van Niekerk tries to kill the ball at the breakdown and is penalised, giving Mortlock another three points.
16 mins: TRY Australia 10-0 South Africa
The Springboks are harshly penalised for collapsing a scrum even though they were pushing forward. Chris Latham's superb penalty touch puts them deep in South Africa territory and from the line-out, the Aussies drive and Jeremy Paul is bundled over. Mortlock converts.
12 mins: South Africa are penalised near their own line. Mortlock goes for goal but the ball hits the post and comes back out.
11 mins: The first real dust up as Australia pile the pressure on the South Africa line. Wallaby centre Stirling Mortlock clears out Ricky Januarie at the ruck but the Springbok scrum-half seems to gouge Mortlock's mouth. Unsurprisingly, Mortlock does not take it very well but after a bit of pushing and shoving, order is restored.
9 mins: Australia have had the better of the play. Fava and Mark Gerrard combine on the wing and Joe van Niekerk has to clear up in the in-goal area.
6 mins: DROP GOAL Australia 3-0 South Africa
Australia get the first points on the board as Larkham fires over a superb drop goal from 41 metres out. That will settle the Brisbane crowd.
4 mins: The first scrum, and a key pointer as to how the Wallabies will perform against the powerful South Africans. Ominously for the home side it is a mess as they are wheeled and number eight Scott Fava is forced to desperately pick the ball up at the back.
2 mins: A frantic start for both sides. The Springboks knock on in contact and Australia try and launch a counter attack. It fizzles out as they spill the ball. The damp has made the ball very difficult to hold onto.
1108: South Africa's Jaco van der Westhuyzen gets the game underway. The ball is caught successfully and Stephen Larkham boots for touch.
1105: The national anthems are completed and as "Waltzing Matilda" rings around the stadium, the sides prepare themselves for kick-off.
1100: Both sides come out onto the field. There has been rain in Brisbane which could affect how adventurous they are.
1053: History is pointing towards a Wallaby victory in Brisbane as they have won every game there since the Suncorp Stadium was redeveloped in 2003 while South Africa have won just one Tri-Nations match away from home since 1998.
However Australia are now on a run of six straight Tri-Nations defeats, a new record and another loss today might end their chances of claiming the 2006 title.
Australia will be looking to bounce back from their opening Tri-Nations defeat against New Zealand when they take on South Africa in Brisbane.
The Aussies, under the guidance of new coach John Connolly, were overpowered by the All Blacks up front and they have worked hard to correct their faults in the scrum.
Number eight Scott Fava comes into side to give a more balanced look to the back row while inside centre Matt Giteau replaces Mat Rogers.
South Africa have admitted that they will target the Aussie scrum as they open their Tri-Nations campaign.
Winger Akona Ndungane and number eight Pierre Spies come into the side.
The Springboks had two victories over Scotland in June before their shock home defeat to France.
Australia: Latham; Gerrard, Mortlock, Giteau, Tuqiri; Larkham, Gregan; Holmes, Paul, Shepherdson; Sharpe, Vickerman; Elsom, Smith, Fava.
Replacements: Hardman, Baxter, Chisholm, Waugh, Cordingley, Rogers, Rathbone.
South Africa: Montgomery; Ndungane, Fourie, Olivier, Habana; van der Westhuyzen, Januarie; du Randt, Smit, van der Linde, Matfield; Rossouw, van Niekerk, Smith, Spies.
Replacements: Coetzee, Andrews, van der Berg, Cronje, du Preez, Bosman, Paulse.
Referee: Paul Honiss (New Zealand)