Giteau and his team-mates were too strong for South Africa
Australia 49 (30)
Tries: Paul, Holmes, Giteau 2, Latham, Chisholm
Cons: Mortlock 5
Pens: Mortlock 2
South Africa 0 (0)
Australia recorded their biggest win over South Africa with a six-try demolition of their hapless Tri-Nations rivals in Brisbane.
The Wallabies took the lead through an early drop-goal before dominating the opening half with tries from Jeremy Paul, Greg Holmes and Matt Giteau.
The error-strewn Springboks did improve slightly but Chris Latham, Giteau and Mark Chisholm sealed a comfortable win.
Stirling Mortlock capped a fine display with 16 points from the boot.
The defeat is the largest losing margin in the history of the Tri-Nations and under-fire South Africa coach Jake White faces a massive task to sort out his side's problems before the clash with New Zealand next week.
Even taking the damp weather into account, the Springboks missed far too many tackles, gave away far too many penalties and their much-vaunted forwards failed to dominate up front as expected.
White has also not settled on a backline and with Jaco van der Westhuyzen having a nightmare at fly-half, his side carried little threat or incision.
Australia on the other hand, will be greatly boosted with how they produced such a commanding display so quickly after the disappointing 32-12 defeat to New Zealand last week.
Scott Fava congratulates Mark Chisholm on Australia's sixth try
They took the lead after just six minutes when Stephen Larkham fired over a long-range drop-goal and it was one-way traffic from then on.
They went further ahead when Paul bundled over from a line-out drive on 16 minutes before Larkham produced a magical break to set up Holmes.
To add to South Africa's misery, lock Victor Matfield was sin-binned on 31 minutes for knocking the ball down from an offside position and Giteau's clinical try just before the break put the result beyond doubt.
South Africa did tighten things up after the break but any opportunities were squandered while Australia's backs continued to run riot.
Giteau's cross-field kick to Lote Tuqiri set up Latham 18 minutes into the second half before Giteau collected Clyde Rathbone's kick-through to claim his second.
The score could have been greater if it was not for Fourie Du Preez, who produced two desperate tackles to hold up Sam Cordingley and Nathan Sharpe in goal.
But the rout was completed five minutes from time when Chisholm finished off a fine attack.
Australia: Latham; Gerrard, Mortlock, Giteau, Tuqiri; Larkham, Gregan; Holmes, Paul, Shepherdson; Sharpe, Vickerman; Elsom, Smith, Fava.
Replacements: Hardman, Baxter, Chisholm, Waugh, Cordingley, Rogers, Rathbone.
South Africa: Montgomery; Ndungane, Fourie, Olivier, Habana; van der Westhuyzen, Januarie; du Randt, Smit, van der Linde, Matfield; Rossouw, van Niekerk, Smith, Spies.
Replacements: Coetzee, Andrews, van der Berg, Cronje, du Preez, Bosman, Paulse.
Referee: Paul Honiss (New Zealand)