Italy's Six Nations clash with Scotland on Saturday could be their last at the Stadio Flaminio unless it is upgraded.
The Stadio Flaminio has the smallest capacity in the Six Nations
Italian rugby officials are keen to extend the capacity of the Rome venue from 24,593 to around 40,000 as well as revamp the ageing facilities.
"I hope we sort the problems out or the Six Nations will move away from Rome," said Giancarlo Dondi, president of the Italian Rugby Federation (FIR).
The FIR have studied the possibility of moving to the northern city of Genoa.
Most top Italian clubs are based in northern Italy and it is believed a northern venue would lead to a bigger attendance from home supporters.
However, it is also thought many away supporters might find a trip to a northern Italian city less appealing than a weekend in Rome.