Full-back Josh Lewsey has recovered from a shoulder injury and been named in England's team to face Scotland in Saturday's Calcutta Cup match.
Lewsey was injured against Wales and missed the Italy match
The only other change to coach Andy Robinson's starting XV that beat Italy is in the pack where prop Julian White replaces the injured Matt Stevens.
On the bench, Perpignan's Perry Freshwater replaces White and hooker George Chuter replaces Lee Mears.
Lewsey's return pushes Tom Voyce to the bench in place of James Simpson-Daniel.
Until his injury against Wales, Lewsey was England's only ever-present player from the 2003 World Cup final, and Robinson said there was no question of leaving him out if he was fit.
"It's good to see Josh back, he's our number one full-back," said Robinson.
"He's had two weeks off but has been able to train, run hard and do a lot of strength work so that was a decision I was always going to make."
Wasps winger Voyce, who has lost his place to club colleague Lewsey, is fit to take his place on the bench despite having three teeth knocked out playing for his club against Bristol last weekend.
In the pack, Leicester prop White earns his first start for England since the opening game of last year's Six Nations.
He played all three Tests on the Lions tour but was left out of the autumn internationals because coach Robinson wanted more mobility in his pack.
England will be looking for a third successive win in this season's Six Nations when they travel to Murrayfield on Saturday.
Scotland's season began in style when they won their opening game against France, but last time out they had Scott Murray sent off as they lost to Wales in Cardiff.
Lewsey, Cueto, Noon, Tindall, Cohen, Hodgson, Ellis; Sheridan, Thompson, White, Borthwick, Grewcock, Worsley, Moody, Corry (capt).
Replacements: Chuter, Freshwater, Shaw, Dallaglio, Dawson, Goode, Voyce