Kenny Logan will end his representative rugby career against the Scotland side for which he was capped 70 times.
Logan is one of several players confirmed for the tour
The winger will play for the Barbarians at Pittodrie in Aberdeen on 24 May.
"It has been the greatest honour of my career to play for my country so many times," said Logan. "Playing for the Baa-Baas has been a great experience.
"And the opportunity to play my last representative game for the Barbarians against a Scotland XV means a lot to me. So it is the perfect swansong."
The 33-year-old Glasgow winger will retire from the playing side of the game at the end of the season.
But he is among a batch of players confirmed for the Barbarians' matches against Scotland and England.
Girvan Dempsey and centre Kevin Maggs were ever-present members of the Ireland squad in the RBS Six Nations matches.
And they will be joined by several other Irish internationals when the full tour party is announced.
The French contingent will include Thomas Castaignede and Sebastien Chabal.
Former Lions players Darren Morris of Wales and England's Mark Regan will vie for front-row selection.
The squad will again be coached by Australian World Cup winner Bob Dwyer.
He will be joined from the southern hemisphere by several top-ranking Wallabies, Springboks and All Blacks for the two-match tour.
The Barbarians face England at Twickenham on Saturday 28 May.
Barbarians president Micky Steele-Bodger said: "Visiting Aberdeen for the match against Scotland is a new departure, but we are confident that it will be a popular one.
"Great touring sides such as the All Blacks, Springboks and Wallabies have played in Aberdeen in the days of the long tours and we are delighted to be part of a new era of top-class representative rugby in the north of Scotland.
"Then we travel south and the match at Twickenham will also test us to the limit because the England XV will be out for revenge after three defeats in the last four matches against us."