Australian props David Fitter and Greg Holmes will make their first starts in Saturday's game against Ireland at Lansdowne Road.
Fitter is uncapped while Holmes has won two caps as a replacement, against France and England on this tour.
The pair replace the injured Matt Dunning and Al Baxter.
The only other changes to the squad beaten 26-16 by England last Saturday see Matt Henjak and Wendell Sailor return to the bench.
Australia coach Eddie Jones has warned against an Irish backlash following their 45-7 thrashing by New Zealand.
"They (Fitter and Holmes) will require enthusiasm and courage," said Jones.
"It is going to be a big thing for them. The Irish have a very experienced front row.
"While Matt Dunning's coming along well, he's just not ready to play at the moment so Holmes will get a chance to start at loose-head.
"We also feel Fitter deserves the opportunity at tight-head after making some good progress on the tour and he's a bloke who is very passionate about scrummaging."
Dunning was carried off in a neck brace when Australia crashed to a record-equalling seventh successive defeat against England last weekend.
Australia: Chris Latham (Queensland Reds), Mark Gerrard (ACT Brumbies), Lote Tuqiri (NSW Waratahs), Morgan Turinui (NSW Waratahs), Drew Mitchell (Queensland Reds), Mat Rogers (NSW Waratahs), George Gregan (ACT Brumbies, capt), George Smith (ACT Brumbies), Phil Waugh (NSW Waratahs), John Roe (Queensland Reds), Nathan Sharpe (Western Force), Hugh McMenamin (Queensland Reds), David Fitter (Western Force), Brendan Cannon (Western Force), Greg Holmes (Queensland Reds)
Replacements: Tatafu Polata-Nau (NSW Waratahs), Al Baxter (NSW Waratahs), Mark Chisholm (ACT Brumbies), Scott Fava (Western Force), Matt Henjak (Western Force), Lloyd Johansson (Queensland Reds), Wendell Sailor (NSW Waratahs)