England have made five changes from the side that lost to Wales for the RBS Six Nations match against France at Twickenham on Sunday.
Mathew Tait, 19, is dropped after just one game
Olly Barkley will play at centre in place of 19-year-old Mathew Tait, who is dropped from the 22 after making his debut in Cardiff.
Scrum-half Harry Ellis replaces Matt Dawson, while Lewis Moody, Martin Corry and Phil Vickery return in the pack.
World Cup-winning prop Vickery is in for the injured Julian White.
In the back row Leicester players Moody and Corry are both fit again.
They replace Andy Hazell, who drops to the bench, and Chris Jones, who is axed from the 22.
Vickery will win his 45th cap after Leicester prop White was ruled out with a neck injury.
White's fellow Leicester front rower Graham Rowntree will win his 50th cap at loose-head while their team-mate Ellis will make his first start at scrum-half.
Veteran number nine Matt Dawson is dropped to the bench where he is joined by Gloucester's Henry Paul, who is recalled following a torrid time in the November internationals last year.
England coach Andy Robinson defended his decision to drop 19-year-old centre Tait after just one cap.
"I'm not here to blame Mathew Tait," said Robinson. "But Olly Barkley offers us a second kicking option.
"(Against Wales) we lacked that real enthusiasm and creativity we had in the autumn. I take responsibility for that.
"I think Mathew Tait is good enough to play for England but we didn't have an effective kicking game last week."
Robinson was delighted to be able to welcome back Moody and Corry after they missed the first game through injury.
"Martin Corry has made a full recovery from his recent elbow injury, and I believe he could have a huge impact on our game," said Robinson.
"Lewis Moody also had some very strong performances in the autumn internationals and has much to offer at openside."
He also praised scrum-half Ellis, saying: "Harry has consistently impressed me with his attitude and ability."
England: J Robinson (Sale, capt); M Cueto (Sale), J Noon (Newcastle), O Barkley (Bath), J Lewsey (Wasps); C Hodgson (Sale), H Ellis (Leicester); G Rowntree (Leicester), S Thompson (Northampton), P Vickery (Gloucester); D Grewcock (Bath), B Kay (Leicester); J Worsley (Wasps), L Moody (Leicester), M Corry (Leicester).
Replacements: A Titterrell (Sale), A Sheridan (Sale), S Borthwick (Bath), A Hazell (Gloucester), M Dawson (Wasps), H Paul (Gloucester), B Cohen (Northampton).