Wales' winless run on South African soil continued after the Springboks claimed a 53-18 win in Pretoria.
South Africa (27) 53:
Tries: Smit, Russell 2, Paulse, Julies, Conradie, Burger.
Cons: Montgomery 6.
Pens: Montgomery 2.
Wales (6) 18:
Tries: Peel, S Williams.
Pens: Henson 2.
Home skipper John Smit opened the try scoring, with Breyton Paulse, Wayne Julies, Bolla Conradie, Schalk Burger and Brent Russell (2) also crossing.
Full-back Percy Montgomery, who plays club rugby in Wales, was also in fine form, adding 18 points with the boot.
Wales had tries from Dwayne Peel and Shane Williams to show, but spent too much time having to defend.
There was no repeat of the record 96-13 loss the last time the teams met at the Loftus Versfeld Stadium in 1998, but Wales know they were outclassed once again.
Springbok lock Victor Matfield and blindside Burger were outstanding in the loose exchanges, while Montgomery at full-back was majestic.
The visitors nearly scored the game's opening try when Williams gathered Nick Robinson's up-and-under to go over, only to be called back for offside.
Fortunately for Wales the Springboks had committed an earlier offence, allowing Gavin Henson to claim some reward by kicking the penalty from the halfway line.
South African pressure soon told, however, as flanker Burger made the hard yards, Jaco van der Westhuyzen provided the darting run and hooker Smit barrelled over for a try.
Montgomery, who plays his club rugby in Wales for the Newport Gwent Dragons, converted his skipper's try and six minutes later added a penalty to give the Boks a 10-3 lead with a quarter of the match gone.
Henson and Montgomery exchanged penalties, before slack Welsh play allowed South Africa to claim their second try.
Wales full-back Henson missed touch with a clearance, allowing Montgomery to charge back and set Matfield on his way.
The rampaging lock swatted aside Gethin Jenkins, before sending supporting wing Russell over under the posts for a converted try.
Wales repeated the error a minute before half-time when Dwayne Peel's loose clearance kick was returned over their try line by Paulse for another seven-pointer.
Welsh bodies continued to be put on the line after the break and number eight Alix Popham was stretchered off after being knocked out, reserve hooker Huw Bennett taking over as a makeshift back row.
Fortune continued to go against Mike Ruddock's side, as South Africa centre Julies exchanged what appeared to be a forward pass with Paulse to go over for his side's fourth try.
Montgomery's missed conversion was his first failure of the afternoon, but he was soon back in the groove with the extras for Russell's second try of the afternoon.
Geo Cronje came on for Quinton Davids to join his brother, Jacques, and become the first pair of Blue Bulls brothers to play a Test at Loftus Versfeld.
But the edge was taken off that moment of Springbok history as Wales enjoyed their best spell of the second half, allowing Peel to dart over under the posts from the base of a ruck.
Henson's conversion narrowed the gap to 39-13, but the Springboks restored their lead as replacement scrum-half Conradie broke away down the left for a converted try.
Fittingly it was left to Burger to take the Springboks over the 50-point barrier with his side's seventh try, Montgomery's kick taking the score to 53-13.
Williams grabbed a late consolation try for Wales, but it was another uncomfortable afternoon at Loftus Versfeld for the men in red.
South Africa: P Montgomery; B Paulse, M Joubert, W Julies, B Russell; J van der Westhuyzen, F du Preez; O du Randt, J Smit (capt), F Rautenbach, Q Davids, V Matfield, S Burger, P Wannenburg, J Cronje.
Replacements: H Shimange, E Andrews, G Cronje, G Britz, B Conradie, H Mentz, G du Toit.
Wales: G Henson; H Luscombe, S Parker, T Shanklin, S Williams; N Robinson, D Peel; G Jenkins, M Davies, Adam Jones, Deiniol Jones, G Llewellyn, Dafydd Jones, C Charvis (capt), A Popham.
Replacements: H Bennett, Duncan Jones, D Morris, J Thomas, M Phillips, C Sweeney, R Williams.