Scotland will play their second Autumn Test with Australia at Hampden Park, the home of Scottish football.
Scotland will play at Hampden and McDiarmid Park
The match will be played on Saturday 20 November with a 14.45 kick-off, while an Old Firm game kicks off at Ibrox on the same day at 12.30.
Scotland last played in Glasgow when Romania were beaten 60-19 as a World Cup warm-up match in 1999.
"It makes sense to showcase rugby in other parts of the country," said SRU Chief Executive Phil Anderton.
The move to Hampden follows the decision to take on Japan at McDiarmid Park, Perth on 13 November.
The home of St Johnstone FC will become the seventh Scottish ground to host an international.
The Saints have a home match that day and have switched the kick-off to 12.45, with the rugby starting at 17.30.
The autumn series begins at Murrayfield with Australia as opponents on 6 November and ends, at the traditional home of Scottish rugby again, against South Africa on 27 November.