Italy number eight Carlo Checchinato has failed a fitness test and is out of Saturday's final RBS Six Nations game against Wales.
Carlo Checcinato failed a fitness test on Friday
Captain Andrea de Rossi moves to the back of the scrum, with lock Marco Bortolami moving to the blindside.
Overmach Parma's Carlo del Fava, 22, comes in at lock to win his first cap.
Checchinato would have become Italy's most-capped international with 84 appearances had he played in Cardiff, but he has a problem ankle.
The veteran Benetton Treviso player is currently tied with scrum-half Alessandro Troncon and should stay that way - as he is expected to end his 14-year Test career after the Wales game.
Italy coach John Kirwin has named Andrea Masi at outside centre in place of Matteo Barbini, with Santiago Dellape forming a new partnership at lock with Del Fava.
Del Fava - who was born in South Africa to an Italian father - makes his Italy debut despite having played just five senior games for Overmach Parma.
The former Natal Sharks and South Africa Under-21player has recently finished serving a two-year ban after testing positive for the banned substance stanozolol.
"I hadn't intended to give him his full debut so soon, but Carlo Checchinato's injury made it necessary," Kirwin said.
"Carlo del Fava is living a dream that any rugby player would love."
Italy: Canale (Benetton Treviso), Mazzucato (Ghial Calvisano), Masi (Viadana), Stoica (Montpellier), Dallan (Benetton Treviso), De Marigny (Overmach Rugby Parma), Griffen (Ghial Calvisano), Lo Cicero (Lazio & Primavera), Ongaro (Benetton Treviso), Castrogiovanni (Ghial Calvisano), Dellape (Benetton Treviso), Del Fava (Overmach Parma), Bortolami (Safio Petrarca Padova), Persico (Leeds Tykes), De Rossi (Ghial Calvisano, capt).
Replacements: Festuccia (SKG Gran Parma), Perugini (Ghial Calvisano), Mandelli (Ghial Calvisano), Orlando (Treviso), Picone (Benetton Treviso), Wakarua (Brescia), Bergamasco (Stade Francais).