Glasgow lock Jason White will make his first start of the RBS Six Nations championship when Scotland face Wales at Murrayfield on Saturday.
Jason White replaces the injured Martin Leslie in the starting line-up
White replaces the injured Martin Leslie, while Bordeaux-Begles centre James McLaren returns for the first time in a year in place of the dropped Brendan Laney.
And Edinburgh's Scott Murray continues in the side despite having been dropped from the original squad until Leslie's withdrawal following a poor display in Paris.
Scotland coach Ian McGeechan had no qualms about keeping Murray in the starting line-up after the lock performed well in training this week.
"When Martin was injured, we thought the balance was right to look at the second row with Scott coming in," said the coach.
"He offers us a great deal and we were looking at the best shape of the pack as we wanted it if Martin wasn't there.
Scott has trained well with us this week
Scotland coach Ian McGeechan
"We thought then that it was obvious we should start with Scott.
"Scott has trained well with us this week. There is no doubt about that."
McGeechan has kept the changes to a minimum despite the 38-3 defeat by France.
The match against the Welsh is being billed as a wooden spoon showdown, with both sides looking for their first victory of the championship.
Centre Kevin Utterson retains his place after winning his first cap in Paris.
Borders team-mate Gregor Townsend keeps his place, despite pressure from Leeds Tykes' Gordon Ross.
But Townsend will move from outside centre to stand-off in the absence of Laney, who has been struggling with a niggling injury.
McLaren returns to the international starting XV for the first time since last year's game against Wales.
Chris Paterson will play on the right wing, with Kenny Logan at No. 11, the positions they filled against France.
Scotland team: Glenn Metcalfe (Glasgow), Chris Paterson (Edinburgh), James McLaren (Bordeaux- Begles), Kevin Utterson (The Borders), Kenny Logan (London Wasps), Gregor Townsend (Borders), Bryan Redpath (Sale Sharks) captain, Tom Smith (Northampton Saints), Gordon Bulloch (Glasgow), Bruce Douglas (Borders), Scott Murray (Edinburgh), Stuart Grimes (Newcastle Falcons), Jason White (Glasgow), Simon Taylor (Edinburgh), Andrew Mower (Newcastle).
Substitutes: Robert Russell (Saracens), Gavin Kerr (Leeds Tykes), Nathan Hines (Edinburgh), Jon Petrie (Glasgow), Mike Blair (Edinburgh), Gordon Ross (Leeds Tykes), Andy Craig (Orrell).