Leicester fly-half Andy Goode scored a total of 32 points as the two-time Heineken Cup champions got off to a winning start in the competition.
Leicester 57 (29)
Tries: Ellis, Lloyd, Varndell, Goode, Chuter, Murphy
Cons: Goode (6)
Pens: Goode (5)
Clermont Au'gne 23 (9)
Tries: Marsh, Scelzo
Cons: Dambielle, McMullen
Pens: Dambielle (2), McMullen
Goode scored a second-half try and slotted over 11 spot kicks to help boost his England credentials.
Tries from Harry Ellis and Leon Lloyd, plus Goode's boot, moved the Tigers 29-9 ahead at half-time.
Tom Varndell, George Chuter and Geordan Murphy all scored after the break to take the game out of Clermont's reach.
Murphy got Leicester's try scoring under way with an interception and electric burst before sending Ellis in under the posts.
He was, however, upstaged with the Tigers' second try as Chuter found captain Martin Corry with a delightful reverse flick before Varndell sent Lloyd sliding in.
Varndell moved from creator to scorer moments after the interval before Clermont briefly got back in the game in the 48th minute when Breyton Paulse seared through the opposition defence and cleared the way for Tony Marsh to touch down.
But seconds later Goode scooped up a loose ball and ran in from 30 metres for a deserved score.
Clermont did their utmost to cut the deficit with a Martin Scelzo try but a raft of changes from the home side added further zest to an already fired-up side.
Chuter produced a delightul one-two in the line-out with Leo Cullen for his score before Murphy rounded off the try count when he latched on to a flamboyant high pass from Varndell.
Goode's points tally, however, left him just five points shy of David Humphreys' record in an individual Heineken Cup match.
Leicester boss Pat Howard:
"We had five top players missing today and it went very well.
"We didn't go out aiming for the bonus point from the start (which they picked up for scoring four tries).
"We only start looking for the bonus point when we've scored the first three tries. Sadly I don't think pool rivals Stade Francais will bat an eyelid."
Leicester: Murphy; Varndell, Smith, Gibson, Lloyd; Goode, Ellis; Moreno, Chuter, Morris; Cullen, Hamilton; Moody, Jennings, Corry.
Replacements: Vesty for Gibson (50), A. Tuilagi for Lloyd (57), Healey for Ellis (59), Buckland for Chuter (66), Holford for Morris (59), Kay for Hamilton (50), Johnson for Jennings (66).
Sin Bin: Kay (72).
Clermont Auvergne: Dambielle, Rougerie, Canale, Marsh, Kiole, McMullen, Moreau, Shvelidze, Ledesma, Zirakashvili, Barrier, Cudmore, Audebert, Vermeulen, Longo-Elia.
Replacements: Scelzo for Dambielle (51), Vigouroux for Barrier (67).
Not Used: Miguel, Emmanuelli, Jacquet, Paulse, Chanal.
Sin Bin: Dambielle (29).