England World Cup-winning flanker Richard Hill grabbed a brace of tries as Saracens opened their Parker Pen Cup campaign with a 45-13 win over Roma.
Hill made a prompt return to club duty
Hill set Sarries on their way to a comfortable victory with the first of their seven tries, five of them coming in the first half.
Centre Ben Johnston also crossed twice, while Frenchman Thomas Castaignede, who starred at fly-half, landed five conversions.
Even without rested skipper Taine Randell and England scrum-half
Kyran Bracken, Saracens had far too much power for Roma to make the return leg at Vicarage Road a formality.
Newcastle, in the absence of England hero Jonny Wilkinson, racked up 10 tries in a 71-10 victory over Spanish minnows La Moraleja Alcobendas in Valladolid.
Wing Tom May led the way with a hat-trick, while Michael Stephenson, Wilkinson's brother Mark and Tongan flanker Epi Taone weighed in with two apiece.
Kiwi centre Mark Mayerhofler grabbed the other try, with fly-half Dave Walder adding eight conversions.
Bath went one better on their trip to Italy, running in 11 tries in a 75-11 thrashing of L'Aquila.
Prop Matt Stevens collected a hat-trick with Scotland wing Simon Danielli and flanker James Scaysbrook both crossing twice.
The prolific Olly Barkley added 10 conversions and a try of his own to finish with 25 points.
The Zurich Premiership leaders - with England pair Iain Balshaw and Danny Grewcock in their starting line-up - led 56-3 at half-time, and needed only one of the four replacements they named on the bench.
Glasgow , having failed to qualify for the Heineken Cup for the first time, began their Parker Pen campaign with a 30-11 victory over Montpellier in Carcasson.
Donnie Macfadyen, Sean Lamont and Sam Pinder all went over for the Scots, with Daniel Parks converting all three in addition to two penalties and a drop goal.
Harlequins, without England stars Will Greenwood and Jason Leonard, were another English side to come away from Spain with a victory.
Quins scored five tries in a 31-18 win over Dulciora El Salvador on Sunday.
But London Irish came unstuck in France against Montauban, tries from Justin Bishop and Kieron Dawson failing to prevent a 30-26 defeat.
The Exiles will nevertheless be confident of overturning that deficit at home.
But Zurich Premiership strugglers Rotherham face an uphill task to qualify after slipping to a 17-10 home defeat to French side Narbonne on Friday.
Two Cedric Rosalen penalties and a Pascal Bazini try gave the visitors an early 11-0 lead.
A penalty and converted try by Jon Benson early in the second half gave the Yorkshire side hope, but two more Rosalen penalties saw Narbonne home.
Irish province Connacht fared better on French soil, six penalties from veteran stand-off Eric Elwood giving his side an 18-10 victory over Beziers.